Cell cycle-related protein expression in vascular dementia and Alzheimer's disease

Recent findings from our and other laboratories indicate that cell cycle-related phenomena may play a key role in the formation of Alzheimer-type pathology and neuronal cell death in both Alzheimer's and cerebro-vascular diseases. In this study we examine the expression patterns of cyclins A, B...

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Bibliographic Details
Published in:Neuroscience letters 1999-08, Vol.271 (1), p.45-48
Main Authors: Smith, M.Z, Nagy, Zs, Esiri, M.M
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Alzheimer Disease - pathology
Alzheimer's disease
Apoptosis
Autopsy
Biological and medical sciences
Cell Cycle - physiology
Cell Nucleus - enzymology
Cell-cycle
Cerebrovascular Disorders - pathology
Cyclin A - analysis
Cyclin B - analysis
Cyclin B1
Cyclin D1 - analysis
Cyclin E - analysis
Cyclins
Cyclins - analysis
Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases
Dementia, Vascular - pathology
Hippocampus - pathology
Humans
Hypoxia
Ischaemia
Medical sciences
Neurology
Neurons - pathology
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Summary:Recent findings from our and other laboratories indicate that cell cycle-related phenomena may play a key role in the formation of Alzheimer-type pathology and neuronal cell death in both Alzheimer's and cerebro-vascular diseases. In this study we examine the expression patterns of cyclins A, B1, D1 and E in neuronal nuclei in the hippocampus in autopsied healthy elderly individuals, Alzheimer's disease patients and subjects suffering from cerebrovascular disease with and without co-existing Alzheimer's disease. Nuclear cyclin B1 and cyclin E expression was detected in hippocampal neurones in each subject category. However, cyclin B1 expression was significantly elevated in the CA1 of patients suffering from cerebro-vascular disease alone, while cyclin E expression was significantly higher in the CA4 subfield in patients suffering from mixed Alzheimer's and cerebro-vascular diseases compared to subjects in other categories. We hypothesize that cell cycle re-entry may occur in healthy elderly people leading to age-related cell death and mild Alzheimer-type pathology in the hippocampus. However, in pathological conditions, the cell cycle arrest may lead either to the development of severe Alzheimer-related pathology or to excess apoptotic cell death as in vascular dementia.
ISSN:0304-3940
1872-7972
DOI:10.1016/S0304-3940(99)00509-1