Early liver differentiation: genetic potentiation and multilevel growth control

Hepatocytes undergo distinct phases of differentiation as they arise from the gut endoderm, coalesce to form the liver, and mature by birth. Gene inactivation and in vivo footprinting studies in mouse embryos have identified regulatory transcription factors and cell signaling molecules that control...

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Bibliographic Details
Published in:Current opinion in genetics & development 1998-10, Vol.8 (5), p.526-531
Main Author: Zaret, Ken
Format: Article
Language:English
Subjects:
Animals
Cell Differentiation
DNA-Binding Proteins
Embryonic and Fetal Development - genetics
Endoderm - physiology
Gastrula - physiology
Gene Expression Regulation, Developmental
Liver - cytology
Liver - embryology
Mice
Morphogenesis - genetics
Transcriptional Activation
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Summary:Hepatocytes undergo distinct phases of differentiation as they arise from the gut endoderm, coalesce to form the liver, and mature by birth. Gene inactivation and in vivo footprinting studies in mouse embryos have identified regulatory transcription factors and cell signaling molecules that control some but not all of these transitions. The latest studies reveal DNA-binding proteins that appear to potentiate gene activation during liver specification and the importance of signals between early hepatocytes and other cell types that promote early liver growth.
ISSN:0959-437X
1879-0380
DOI:10.1016/S0959-437X(98)80006-3