Variability in the composition of physiologic duodenogastric reflux

Duodenogastric reflux has long been associated with various diseases of the foregut. Even though bile is often used as a marker, duodenogastric reflux consists of other components such as pancreatic juice and duodenal secretions. The aim of this study was to investigate the occurrence of duodenogast...

Full description

Saved in:
Bibliographic Details
Published in:Journal of gastrointestinal surgery 1999-07, Vol.3 (4), p.389-396
Main Authors: Fuchs, Karl-Hermann, Maroske, Jörn, Fein, Martin, Tigges, Harald, Ritter, Manfred P., Heimbucher, Johannes, Thiede, Arnulf
Format: Article
Language:English
Subjects:
Adult
Amylases - analysis
Bile - chemistry
bile reflux
Bilirubin - chemistry
Duodenogastric reflux
Duodenogastric Reflux - enzymology
Duodenogastric Reflux - metabolism
Duodenogastric Reflux - physiopathology
Duodenum - metabolism
Female
Gastrointestinal Contents - chemistry
Gastrointestinal diseases
Humans
Hydrogen-Ion Concentration
Intestinal Secretions - chemistry
Intubation, Gastrointestinal - instrumentation
Lipase - analysis
Male
Monitoring, Ambulatory - instrumentation
Pancreatic Elastase - analysis
pancreatic enzymes
Pancreatic Juice - chemistry
Pancreatin - analysis
reflux disease
Statistics as Topic
Stomach - physiopathology
Throat
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Duodenogastric reflux has long been associated with various diseases of the foregut. Even though bile is often used as a marker, duodenogastric reflux consists of other components such as pancreatic juice and duodenal secretions. The aim of this study was to investigate the occurrence of duodenogastric reflux, its components, and the variability of its composition in normal subjects. Twenty healthy volunteers (7 men and 13 women) whose median age was 24 years underwent combined 24-hour bilirubin and gastric pH monitoring and intraluminal gastric aspiration. All probes were placed at 5 cm below the lower border of the lower esophageal sphincter. Aspiration was performed hourly and at any time when bilirubin and/or pH monitoring showed signs of duodenogastric reflux. Elastase and amylase were measured in the aspirate. All volunteers had episodes of physiologic duodenogastric reflux. A total of 70 episodes of duodenogastric reflux were registered with a median of three episodes (range 1 to 8) per subject. Most bile reflux occurred separately from pancreatic enzyme reflux. Pancreatic enzyme aspirate was significantly more often associated with a rise in pH in comparison to bile reflux ( P
ISSN:1091-255X
1873-4626
DOI:10.1016/S1091-255X(99)80055-9