Loading…
Semisynthesis and Cytotoxicity of Styryl-Lactone Derivatives
The cytotoxicity and the cell-cycle action of altholactone (1), goniofufurone (2), and eight altholactone derivatives (5−12), were determined in vitro on L-1210 cells. Semisyntheses and structure−activity relationships of these compounds are described. The results of this study suggest that the cyto...
Saved in:
Published in: | Journal of natural products (Washington, D.C.) D.C.), 1999-08, Vol.62 (8), p.1106-1109 |
---|---|
Main Authors: | , , , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
cited_by | cdi_FETCH-LOGICAL-a468t-29e4b707cb5cd5f58cd858e42a90623d308afac5f8c9fe69e199d732c20f81da3 |
---|---|
cites | cdi_FETCH-LOGICAL-a468t-29e4b707cb5cd5f58cd858e42a90623d308afac5f8c9fe69e199d732c20f81da3 |
container_end_page | 1109 |
container_issue | 8 |
container_start_page | 1106 |
container_title | Journal of natural products (Washington, D.C.) |
container_volume | 62 |
creator | Bermejo, Almudena Léonce, Stéphane Cabedo, Nuria Andreu, Inmaculada Caignard, Daniel H Atassi, Ghanem Cortes, Diego |
description | The cytotoxicity and the cell-cycle action of altholactone (1), goniofufurone (2), and eight altholactone derivatives (5−12), were determined in vitro on L-1210 cells. Semisyntheses and structure−activity relationships of these compounds are described. The results of this study suggest that the cytotoxicity of altholactone (1), 11-nitro-altholactone (8), and 7-chloro-6,7-dihydroaltholactone (10) is due to the accumulation of the cells in the G2 + M phase of the cell cycle. |
doi_str_mv | 10.1021/np990089q |
format | article |
fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_70038306</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>70038306</sourcerecordid><originalsourceid>FETCH-LOGICAL-a468t-29e4b707cb5cd5f58cd858e42a90623d308afac5f8c9fe69e199d732c20f81da3</originalsourceid><addsrcrecordid>eNpt0MFu1DAQBmALgei2cOAFIAdA4hAY23FsS1zQFijSCpC2RYiLNevYkJKNt7a3at4eV1kVDpzmMJ9-zfyEPKHwmgKjb8ad1gBKX90jCyoY1C0wcZ8sgLa85qptjshxSpcAwEGLh-SIQiM1p3xB3q7dtk_TmH-51KcKx65aTjnkcNPbPk9V8NU6T3Ea6hXaHEZXnbrYX2Pur116RB54HJJ7fJgn5OLD-_PlWb368vHT8t2qxqZVuWbaNRsJ0m6E7YQXynZKKNcw1NAy3nFQ6NEKr6z2rtWOat1JziwDr2iH_IS8nHN3MVztXcqm3GzdMODowj4ZWR5THNoCX83QxpBSdN7sYr_FOBkK5rYqc1dVsU8PofvN1nX_yLmbAp4fACaLg4842j79dVpQKURh9cz6lN3N3Rrjb9NKLoU5_7o238-kWqofn8234p_N3mMw-DOWyIs1A8qBaQGNuk18MQu0yVyGfRxLuf_54A_s8pVH</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>70038306</pqid></control><display><type>article</type><title>Semisynthesis and Cytotoxicity of Styryl-Lactone Derivatives</title><source>American Chemical Society:Jisc Collections:American Chemical Society Read & Publish Agreement 2022-2024 (Reading list)</source><creator>Bermejo, Almudena ; Léonce, Stéphane ; Cabedo, Nuria ; Andreu, Inmaculada ; Caignard, Daniel H ; Atassi, Ghanem ; Cortes, Diego</creator><creatorcontrib>Bermejo, Almudena ; Léonce, Stéphane ; Cabedo, Nuria ; Andreu, Inmaculada ; Caignard, Daniel H ; Atassi, Ghanem ; Cortes, Diego</creatorcontrib><description>The cytotoxicity and the cell-cycle action of altholactone (1), goniofufurone (2), and eight altholactone derivatives (5−12), were determined in vitro on L-1210 cells. Semisyntheses and structure−activity relationships of these compounds are described. The results of this study suggest that the cytotoxicity of altholactone (1), 11-nitro-altholactone (8), and 7-chloro-6,7-dihydroaltholactone (10) is due to the accumulation of the cells in the G2 + M phase of the cell cycle.</description><identifier>ISSN: 0163-3864</identifier><identifier>EISSN: 1520-6025</identifier><identifier>DOI: 10.1021/np990089q</identifier><identifier>PMID: 10479313</identifier><identifier>CODEN: JNPRDF</identifier><language>eng</language><publisher>Washington, DC: American Chemical Society</publisher><subject>altholactone ; Animals ; Antineoplastic agents ; Antineoplastic Agents, Phytogenic - chemical synthesis ; Antineoplastic Agents, Phytogenic - pharmacology ; biochemical pathways ; Biological and medical sciences ; cell cycle ; cell lines ; chemical constituents of plants ; chemical reactions ; chemical structure ; cytotoxic compounds ; derivatives ; Drug Screening Assays, Antitumor ; General aspects ; goniofufurone ; Goniothalamus ; goniothalamus arvensis ; l-1210 cell lines ; lactones ; Lactones - chemical synthesis ; Lactones - pharmacology ; Leukemia L1210 - drug therapy ; Medical sciences ; medicinal plants ; Mice ; Molecular Conformation ; New Guinea ; Pharmacology. Drug treatments ; Plants, Medicinal - chemistry ; precursors ; regulation ; spectral analysis ; stearic acid ; structure-activity relationships ; synthesis ; Tumor Cells, Cultured</subject><ispartof>Journal of natural products (Washington, D.C.), 1999-08, Vol.62 (8), p.1106-1109</ispartof><rights>Copyright © 1999 American Chemical Society and American Society of Pharmacognosy</rights><rights>1999 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a468t-29e4b707cb5cd5f58cd858e42a90623d308afac5f8c9fe69e199d732c20f81da3</citedby><cites>FETCH-LOGICAL-a468t-29e4b707cb5cd5f58cd858e42a90623d308afac5f8c9fe69e199d732c20f81da3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1951755$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10479313$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bermejo, Almudena</creatorcontrib><creatorcontrib>Léonce, Stéphane</creatorcontrib><creatorcontrib>Cabedo, Nuria</creatorcontrib><creatorcontrib>Andreu, Inmaculada</creatorcontrib><creatorcontrib>Caignard, Daniel H</creatorcontrib><creatorcontrib>Atassi, Ghanem</creatorcontrib><creatorcontrib>Cortes, Diego</creatorcontrib><title>Semisynthesis and Cytotoxicity of Styryl-Lactone Derivatives</title><title>Journal of natural products (Washington, D.C.)</title><addtitle>J. Nat. Prod</addtitle><description>The cytotoxicity and the cell-cycle action of altholactone (1), goniofufurone (2), and eight altholactone derivatives (5−12), were determined in vitro on L-1210 cells. Semisyntheses and structure−activity relationships of these compounds are described. The results of this study suggest that the cytotoxicity of altholactone (1), 11-nitro-altholactone (8), and 7-chloro-6,7-dihydroaltholactone (10) is due to the accumulation of the cells in the G2 + M phase of the cell cycle.</description><subject>altholactone</subject><subject>Animals</subject><subject>Antineoplastic agents</subject><subject>Antineoplastic Agents, Phytogenic - chemical synthesis</subject><subject>Antineoplastic Agents, Phytogenic - pharmacology</subject><subject>biochemical pathways</subject><subject>Biological and medical sciences</subject><subject>cell cycle</subject><subject>cell lines</subject><subject>chemical constituents of plants</subject><subject>chemical reactions</subject><subject>chemical structure</subject><subject>cytotoxic compounds</subject><subject>derivatives</subject><subject>Drug Screening Assays, Antitumor</subject><subject>General aspects</subject><subject>goniofufurone</subject><subject>Goniothalamus</subject><subject>goniothalamus arvensis</subject><subject>l-1210 cell lines</subject><subject>lactones</subject><subject>Lactones - chemical synthesis</subject><subject>Lactones - pharmacology</subject><subject>Leukemia L1210 - drug therapy</subject><subject>Medical sciences</subject><subject>medicinal plants</subject><subject>Mice</subject><subject>Molecular Conformation</subject><subject>New Guinea</subject><subject>Pharmacology. Drug treatments</subject><subject>Plants, Medicinal - chemistry</subject><subject>precursors</subject><subject>regulation</subject><subject>spectral analysis</subject><subject>stearic acid</subject><subject>structure-activity relationships</subject><subject>synthesis</subject><subject>Tumor Cells, Cultured</subject><issn>0163-3864</issn><issn>1520-6025</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><recordid>eNpt0MFu1DAQBmALgei2cOAFIAdA4hAY23FsS1zQFijSCpC2RYiLNevYkJKNt7a3at4eV1kVDpzmMJ9-zfyEPKHwmgKjb8ad1gBKX90jCyoY1C0wcZ8sgLa85qptjshxSpcAwEGLh-SIQiM1p3xB3q7dtk_TmH-51KcKx65aTjnkcNPbPk9V8NU6T3Ea6hXaHEZXnbrYX2Pur116RB54HJJ7fJgn5OLD-_PlWb368vHT8t2qxqZVuWbaNRsJ0m6E7YQXynZKKNcw1NAy3nFQ6NEKr6z2rtWOat1JziwDr2iH_IS8nHN3MVztXcqm3GzdMODowj4ZWR5THNoCX83QxpBSdN7sYr_FOBkK5rYqc1dVsU8PofvN1nX_yLmbAp4fACaLg4842j79dVpQKURh9cz6lN3N3Rrjb9NKLoU5_7o238-kWqofn8234p_N3mMw-DOWyIs1A8qBaQGNuk18MQu0yVyGfRxLuf_54A_s8pVH</recordid><startdate>19990801</startdate><enddate>19990801</enddate><creator>Bermejo, Almudena</creator><creator>Léonce, Stéphane</creator><creator>Cabedo, Nuria</creator><creator>Andreu, Inmaculada</creator><creator>Caignard, Daniel H</creator><creator>Atassi, Ghanem</creator><creator>Cortes, Diego</creator><general>American Chemical Society</general><general>American Society of Pharmacognosy</general><scope>FBQ</scope><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19990801</creationdate><title>Semisynthesis and Cytotoxicity of Styryl-Lactone Derivatives</title><author>Bermejo, Almudena ; Léonce, Stéphane ; Cabedo, Nuria ; Andreu, Inmaculada ; Caignard, Daniel H ; Atassi, Ghanem ; Cortes, Diego</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a468t-29e4b707cb5cd5f58cd858e42a90623d308afac5f8c9fe69e199d732c20f81da3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>altholactone</topic><topic>Animals</topic><topic>Antineoplastic agents</topic><topic>Antineoplastic Agents, Phytogenic - chemical synthesis</topic><topic>Antineoplastic Agents, Phytogenic - pharmacology</topic><topic>biochemical pathways</topic><topic>Biological and medical sciences</topic><topic>cell cycle</topic><topic>cell lines</topic><topic>chemical constituents of plants</topic><topic>chemical reactions</topic><topic>chemical structure</topic><topic>cytotoxic compounds</topic><topic>derivatives</topic><topic>Drug Screening Assays, Antitumor</topic><topic>General aspects</topic><topic>goniofufurone</topic><topic>Goniothalamus</topic><topic>goniothalamus arvensis</topic><topic>l-1210 cell lines</topic><topic>lactones</topic><topic>Lactones - chemical synthesis</topic><topic>Lactones - pharmacology</topic><topic>Leukemia L1210 - drug therapy</topic><topic>Medical sciences</topic><topic>medicinal plants</topic><topic>Mice</topic><topic>Molecular Conformation</topic><topic>New Guinea</topic><topic>Pharmacology. Drug treatments</topic><topic>Plants, Medicinal - chemistry</topic><topic>precursors</topic><topic>regulation</topic><topic>spectral analysis</topic><topic>stearic acid</topic><topic>structure-activity relationships</topic><topic>synthesis</topic><topic>Tumor Cells, Cultured</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bermejo, Almudena</creatorcontrib><creatorcontrib>Léonce, Stéphane</creatorcontrib><creatorcontrib>Cabedo, Nuria</creatorcontrib><creatorcontrib>Andreu, Inmaculada</creatorcontrib><creatorcontrib>Caignard, Daniel H</creatorcontrib><creatorcontrib>Atassi, Ghanem</creatorcontrib><creatorcontrib>Cortes, Diego</creatorcontrib><collection>AGRIS</collection><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of natural products (Washington, D.C.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bermejo, Almudena</au><au>Léonce, Stéphane</au><au>Cabedo, Nuria</au><au>Andreu, Inmaculada</au><au>Caignard, Daniel H</au><au>Atassi, Ghanem</au><au>Cortes, Diego</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Semisynthesis and Cytotoxicity of Styryl-Lactone Derivatives</atitle><jtitle>Journal of natural products (Washington, D.C.)</jtitle><addtitle>J. Nat. Prod</addtitle><date>1999-08-01</date><risdate>1999</risdate><volume>62</volume><issue>8</issue><spage>1106</spage><epage>1109</epage><pages>1106-1109</pages><issn>0163-3864</issn><eissn>1520-6025</eissn><coden>JNPRDF</coden><abstract>The cytotoxicity and the cell-cycle action of altholactone (1), goniofufurone (2), and eight altholactone derivatives (5−12), were determined in vitro on L-1210 cells. Semisyntheses and structure−activity relationships of these compounds are described. The results of this study suggest that the cytotoxicity of altholactone (1), 11-nitro-altholactone (8), and 7-chloro-6,7-dihydroaltholactone (10) is due to the accumulation of the cells in the G2 + M phase of the cell cycle.</abstract><cop>Washington, DC</cop><cop>Glendale, AZ</cop><pub>American Chemical Society</pub><pmid>10479313</pmid><doi>10.1021/np990089q</doi><tpages>4</tpages></addata></record> |
fulltext | fulltext |
identifier | ISSN: 0163-3864 |
ispartof | Journal of natural products (Washington, D.C.), 1999-08, Vol.62 (8), p.1106-1109 |
issn | 0163-3864 1520-6025 |
language | eng |
recordid | cdi_proquest_miscellaneous_70038306 |
source | American Chemical Society:Jisc Collections:American Chemical Society Read & Publish Agreement 2022-2024 (Reading list) |
subjects | altholactone Animals Antineoplastic agents Antineoplastic Agents, Phytogenic - chemical synthesis Antineoplastic Agents, Phytogenic - pharmacology biochemical pathways Biological and medical sciences cell cycle cell lines chemical constituents of plants chemical reactions chemical structure cytotoxic compounds derivatives Drug Screening Assays, Antitumor General aspects goniofufurone Goniothalamus goniothalamus arvensis l-1210 cell lines lactones Lactones - chemical synthesis Lactones - pharmacology Leukemia L1210 - drug therapy Medical sciences medicinal plants Mice Molecular Conformation New Guinea Pharmacology. Drug treatments Plants, Medicinal - chemistry precursors regulation spectral analysis stearic acid structure-activity relationships synthesis Tumor Cells, Cultured |
title | Semisynthesis and Cytotoxicity of Styryl-Lactone Derivatives |
url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-12T08%3A08%3A07IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Semisynthesis%20and%20Cytotoxicity%20of%20Styryl-Lactone%20Derivatives&rft.jtitle=Journal%20of%20natural%20products%20(Washington,%20D.C.)&rft.au=Bermejo,%20Almudena&rft.date=1999-08-01&rft.volume=62&rft.issue=8&rft.spage=1106&rft.epage=1109&rft.pages=1106-1109&rft.issn=0163-3864&rft.eissn=1520-6025&rft.coden=JNPRDF&rft_id=info:doi/10.1021/np990089q&rft_dat=%3Cproquest_cross%3E70038306%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-a468t-29e4b707cb5cd5f58cd858e42a90623d308afac5f8c9fe69e199d732c20f81da3%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=70038306&rft_id=info:pmid/10479313&rfr_iscdi=true |