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Semisynthesis and Cytotoxicity of Styryl-Lactone Derivatives

The cytotoxicity and the cell-cycle action of altholactone (1), goniofufurone (2), and eight altholactone derivatives (5−12), were determined in vitro on L-1210 cells. Semisyntheses and structure−activity relationships of these compounds are described. The results of this study suggest that the cyto...

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Published in:Journal of natural products (Washington, D.C.) D.C.), 1999-08, Vol.62 (8), p.1106-1109
Main Authors: Bermejo, Almudena, Léonce, Stéphane, Cabedo, Nuria, Andreu, Inmaculada, Caignard, Daniel H, Atassi, Ghanem, Cortes, Diego
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cited_by cdi_FETCH-LOGICAL-a468t-29e4b707cb5cd5f58cd858e42a90623d308afac5f8c9fe69e199d732c20f81da3
cites cdi_FETCH-LOGICAL-a468t-29e4b707cb5cd5f58cd858e42a90623d308afac5f8c9fe69e199d732c20f81da3
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container_issue 8
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container_title Journal of natural products (Washington, D.C.)
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creator Bermejo, Almudena
Léonce, Stéphane
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Atassi, Ghanem
Cortes, Diego
description The cytotoxicity and the cell-cycle action of altholactone (1), goniofufurone (2), and eight altholactone derivatives (5−12), were determined in vitro on L-1210 cells. Semisyntheses and structure−activity relationships of these compounds are described. The results of this study suggest that the cytotoxicity of altholactone (1), 11-nitro-altholactone (8), and 7-chloro-6,7-dihydroaltholactone (10) is due to the accumulation of the cells in the G2 + M phase of the cell cycle.
doi_str_mv 10.1021/np990089q
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The results of this study suggest that the cytotoxicity of altholactone (1), 11-nitro-altholactone (8), and 7-chloro-6,7-dihydroaltholactone (10) is due to the accumulation of the cells in the G2 + M phase of the cell cycle.</description><identifier>ISSN: 0163-3864</identifier><identifier>EISSN: 1520-6025</identifier><identifier>DOI: 10.1021/np990089q</identifier><identifier>PMID: 10479313</identifier><identifier>CODEN: JNPRDF</identifier><language>eng</language><publisher>Washington, DC: American Chemical Society</publisher><subject>altholactone ; Animals ; Antineoplastic agents ; Antineoplastic Agents, Phytogenic - chemical synthesis ; Antineoplastic Agents, Phytogenic - pharmacology ; biochemical pathways ; Biological and medical sciences ; cell cycle ; cell lines ; chemical constituents of plants ; chemical reactions ; chemical structure ; cytotoxic compounds ; derivatives ; Drug Screening Assays, Antitumor ; General aspects ; goniofufurone ; Goniothalamus ; goniothalamus arvensis ; l-1210 cell lines ; lactones ; Lactones - chemical synthesis ; Lactones - pharmacology ; Leukemia L1210 - drug therapy ; Medical sciences ; medicinal plants ; Mice ; Molecular Conformation ; New Guinea ; Pharmacology. 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source American Chemical Society:Jisc Collections:American Chemical Society Read & Publish Agreement 2022-2024 (Reading list)
subjects altholactone
Animals
Antineoplastic agents
Antineoplastic Agents, Phytogenic - chemical synthesis
Antineoplastic Agents, Phytogenic - pharmacology
biochemical pathways
Biological and medical sciences
cell cycle
cell lines
chemical constituents of plants
chemical reactions
chemical structure
cytotoxic compounds
derivatives
Drug Screening Assays, Antitumor
General aspects
goniofufurone
Goniothalamus
goniothalamus arvensis
l-1210 cell lines
lactones
Lactones - chemical synthesis
Lactones - pharmacology
Leukemia L1210 - drug therapy
Medical sciences
medicinal plants
Mice
Molecular Conformation
New Guinea
Pharmacology. Drug treatments
Plants, Medicinal - chemistry
precursors
regulation
spectral analysis
stearic acid
structure-activity relationships
synthesis
Tumor Cells, Cultured
title Semisynthesis and Cytotoxicity of Styryl-Lactone Derivatives
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