Inheritance and genetic mapping of the campus syndrome (CPS): a high-frequency tremor disease in pigs

A new progressive tremor disorder called Campus syndrome (CPS) was observed among the progeny of a normal boar of the Pietrain breed in Germany. Extensive backcross experiments indicate that CPS is inherited as an autosomal dominant trait, and the founder boar, Campus, is believed to be a gonadal mo...

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Bibliographic Details
Published in:The Journal of heredity 1999-07, Vol.90 (4), p.472-476
Main Authors: Tammen, I, Schulze, C, Chavez-Moreno, J, Waberski, D, Simon, D, Harlizius, B
Format: Article
Language:English
Subjects:
Animals
Chromosome Mapping
Chromosomes, Human, Pair 14
Disease
Female
Genetic Markers
Genetics
Heredity
Hogs
Humans
Lod Score
Male
Microsatellite Repeats
Pedigree
Pietrain
Swine - genetics
Swine Diseases - genetics
Tremor - genetics
Tremor - veterinary
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Summary:A new progressive tremor disorder called Campus syndrome (CPS) was observed among the progeny of a normal boar of the Pietrain breed in Germany. Extensive backcross experiments indicate that CPS is inherited as an autosomal dominant trait, and the founder boar, Campus, is believed to be a gonadal mosaic. A linkage analysis of 57 animals mapped the CPS gene to a region on porcine chromosome 7 flanked by the markers SW1418 and SW352, which is homologous to a part of human chromosome (HSA) 14. Human dominant distal myopathy type 1 (MPD1) has been mapped to the homologous region of HSA14. As the myopathological findings in MDP1 show striking similarities to CPS, this porcine disorder may serve as an animal model for MPD1.
ISSN:0022-1503
1465-7333
DOI:10.1093/jhered/90.4.472