Chandipura virus: A major cause of acute encephalitis in children in North Telangana, Andhra Pradesh, India

A hospital-based surveillance was undertaken between May 2005 and April 2006 to elucidate the contribution of Chandipura virus (CHPV) to acute viral encephalitis cases in children, seroconversion in recovered cases and to compare the seroprevalences of anti-CHPV IgM and N antibodies in areas reporti...

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Bibliographic Details
Published in:Journal of medical virology 2008-01, Vol.80 (1), p.118-124
Main Authors: Tandale, Babasaheb V, Tikute, Sanjaykumar S, Arankalle, Vidya A, Sathe, Padmakar S, Joshi, Manohar V, Ranadive, Satish N, Kanojia, Phoolchand C, Eshwarachary, D, Kumarswamy, M, Mishra, Akhilesh C
Format: Article
Language:English
Subjects:
Antibodies, Viral - blood
Biological and medical sciences
Brain - virology
Chandipura virus
Child
childhood acute viral encephalitis
Disease Outbreaks
Encephalitis, Viral - diagnosis
Encephalitis, Viral - epidemiology
Encephalitis, Viral - mortality
Encephalitis, Viral - virology
Fundamental and applied biological sciences. Psychology
Human viral diseases
Humans
Immunoglobulin M - blood
India - epidemiology
Infectious diseases
Medical sciences
Microbiology
Miscellaneous
seroconversion
Seroepidemiologic Studies
seroepidemiological surveys
surveillance
Survival Rate
Vesiculovirus - genetics
Vesiculovirus - immunology
Vesiculovirus - isolation & purification
Vesiculovirus - pathogenicity
Viral diseases
Virology
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Summary:A hospital-based surveillance was undertaken between May 2005 and April 2006 to elucidate the contribution of Chandipura virus (CHPV) to acute viral encephalitis cases in children, seroconversion in recovered cases and to compare the seroprevalences of anti-CHPV IgM and N antibodies in areas reporting cases with those without any case of acute viral encephalitis. During this period, 90 cases of acute encephalitis were hospitalized in the pediatric wards of Mahatma Gandhi Memorial (MGM) Hospital, Warangal. There were 49 deaths (Case Fatality Rate, i.e., CFR of 54.4%). Clinical samples and records were obtained from 52 suspected cases. The cases were below 15 years, majority in 0-4 years (35/52, 67.3%). Computerized tomography (CT) scans and cerebro-spinal fluid (CSF) picture favored viral etiology. No neurological sequelae were observed. CHPV etiology was detected in 25 cases (48.1%, n = 52; RNA in 20, IgM in 3 and N antibody seroconversion in 2). JEV etiology was detected in 5 cases (IgM in 4 cases and seroconversion in 1 case). Anti-CHPV IgM seroprevalence in contacts (26/167, 15.6%) was significantly higher (P < 0.05) than in non-contacts (11/430, 2.6%); which was also observed in children
ISSN:0146-6615
1096-9071
DOI:10.1002/jmv.21041