Kidney dysfunction and fatal cardiovascular disease—an association independent of atherosclerotic events: Results from the Health, Aging, and Body Composition (Health ABC) study

Background Impaired kidney function has been associated with increased risk for death, myocardial infarction, stroke, and heart failure in high-risk populations. We evaluated whether impaired kidney function predicted risk of fatal cardiovascular disease independent of prevalent and incident cardiov...

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Bibliographic Details
Published in:The American heart journal 2008, Vol.155 (1), p.62-68
Main Authors: Deo, Rajat, MD, Wassel Fyr, Christina L., MS, Fried, Linda F., MD, MPH, Newman, Anne B., MD, MPH, Harris, Tamara B., MD, MS, Angleman, Sara, Green, Christie, MD, Kritchevsky, Stephen B., PhD, Chertow, Glenn M., MD, MPH, Cummings, Steven R., MD, Shlipak, Michael G., MD, MPH
Format: Article
Language:English
Subjects:
Age Distribution
Aged
Aging - physiology
Atherosclerosis (general aspects, experimental research)
Atherosclerosis - diagnosis
Atherosclerosis - epidemiology
Biological and medical sciences
Biomarkers - blood
Blood and lymphatic vessels
Body Composition
Body mass index
Cardiology. Vascular system
Cardiovascular
Cardiovascular disease
Cardiovascular Diseases - diagnosis
Cardiovascular Diseases - epidemiology
Cause of Death
Cholesterol
Cohort Studies
Comorbidity
Confidence Intervals
Creatinine - blood
Cystatin C
Cystatins - blood
Demographics
Enzymes
Female
Glomerular Filtration Rate
Glucose
Health Status
Health Surveys
Heart attacks
Humans
Incidence
Kidney Diseases - diagnosis
Kidney Diseases - epidemiology
Kidney Function Tests
Lipoproteins
Male
Medical sciences
Mens health
Mortality
Older people
Probability
Prognosis
Proportional Hazards Models
Sex Distribution
Stroke
Survival Analysis
Womens health
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Summary:Background Impaired kidney function has been associated with increased risk for death, myocardial infarction, stroke, and heart failure in high-risk populations. We evaluated whether impaired kidney function predicted risk of fatal cardiovascular disease independent of prevalent and incident cardiovascular events. Methods The Health, Aging, and Body Composition study is a cohort of well-functioning, elderly participants aged 70 to 79 years at entry. We measured serum cystatin C and creatinine from baseline plasma samples of 3044 participants and followed them over 6 years, examining the associations among kidney function, cardiovascular death, and incident cardiovascular events. Cystatin C was categorized as low (
ISSN:0002-8703
1097-6744
DOI:10.1016/j.ahj.2007.08.012