Isoflavone content of infant formulas and the metabolic fate of these phytoestrogens in early life

Soy-based infant formulas have been in use for >30 y. These formulas are manufactured from soy protein isolates and contain significant amounts of phytoestrogens of the isoflavone class. As determined by HPLC, the isoflavone compositions of commercially available formulas are similar qualitativel...

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Bibliographic Details
Published in:The American journal of clinical nutrition 1998-12, Vol.68 (6), p.1453S-1461S
Main Authors: SETCHELL, K. D. R, ZIMMER-NICHEMIAS, L, JINNAN CAI, HEUBI, J. E
Format: Article
Language:English
Subjects:
Adult
Animals
Babies
Baby foods
Biological and medical sciences
Cattle
Chromans - analysis
Chromans - metabolism
Chromatography, High Pressure Liquid
Enzyme Inhibitors - analysis
Enzyme Inhibitors - metabolism
Equol
Estrogens, Non-Steroidal - analysis
Estrogens, Non-Steroidal - metabolism
Feeding. Feeding behavior
Female
Fundamental and applied biological sciences. Psychology
Genistein - analysis
Genistein - metabolism
Humans
Infant
Infant Food - analysis
Infant, Newborn
Isoflavones - analysis
Isoflavones - metabolism
Metabolism
Milk, Human - chemistry
Milk, Human - metabolism
Monoamine Oxidase Inhibitors - analysis
Monoamine Oxidase Inhibitors - metabolism
Soybean Proteins - administration & dosage
Soybean Proteins - analysis
Soybean Proteins - metabolism
Soybeans
Vertebrates: anatomy and physiology, studies on body, several organs or systems
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Summary:Soy-based infant formulas have been in use for >30 y. These formulas are manufactured from soy protein isolates and contain significant amounts of phytoestrogens of the isoflavone class. As determined by HPLC, the isoflavone compositions of commercially available formulas are similar qualitatively and quantitatively and are consistent with the isoflavone composition of soy protein isolates. Genistein, found predominantly in the form of glycosidic conjugates, accounts for >65% of the isoflavones in soy-based formulas. Total isoflavone concentrations of soy-based formulas prepared for infant feeding range from 32 to 47 mg/L, whereas isoflavone concentrations in human breast milk are only 5.6 +/- 4.4 microg/L (mean +/- SD, n = 9). Infants fed soy-based formulas are therefore exposed to 22-45 mg isoflavones/d (6-11 mg x kg body wt(-1) x d(-1)), whereas the intake of these phytoestrogens from human milk is negligible (
ISSN:0002-9165
1938-3207
DOI:10.1093/ajcn/68.6.1453S