Characterization of Rabies virus isolated from canids and identification of the main wild canid host in Northeastern Brazil

The rabies cases in dogs and wild canids in Northeastern Brazil are a public and animal health problem. This paper describes the identities of the coding region of the N-gene of Rabies virus (RABV) isolated in canids from Northeastern Brazil. The genetic tree generated using the sequence data descri...

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Bibliographic Details
Published in:Virus research 2008-01, Vol.131 (1), p.33-46
Main Authors: Carnieli, Pedro, Fahl, Willian de Oliveira, Castilho, Juliana Galera, Oliveira, Rafael de Novaes, Macedo, Carla Isabel, Durymanova, Ekaterina, Jorge, Rodrigo S.P., Morato, Ronaldo G., Spíndola, Romualdo O., Machado, Lindenrberg M., Sá, José E. Úngar de, Carrieri, Maria Luiza, Kotait, Ivanete
Format: Article
Language:English
Subjects:
Animals
Animals, Wild - virology
Antigens, Viral
Brazil
Brazil - epidemiology
Canidae - virology
Cerdocyon thous
Genes, Viral
Molecular Epidemiology
mtDNA
Nucleoprotein
Nucleoproteins - chemistry
Nucleoproteins - genetics
Phylogeny
Rabies - epidemiology
Rabies - veterinary
Rabies virus
Rabies virus - classification
Rabies virus - genetics
Rabies virus - isolation & purification
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Summary:The rabies cases in dogs and wild canids in Northeastern Brazil are a public and animal health problem. This paper describes the identities of the coding region of the N-gene of Rabies virus (RABV) isolated in canids from Northeastern Brazil. The genetic tree generated using the sequence data described here divided the cluster BRAZILAN CANIDS into two subclusters (DOG-RELATED STRAINS and WILD CANID-RELATED STRAINS) with identities greater than those already described. The two subclusters are sub-divided into geographic groups related to the origin of the isolates, suggesting a long-standing ecological coexistence of the sequence types characteristic of the groups. This article also analyzes the 513-nucleotide stretch of the mitochondrial DNA control region of rabies-positive canids from Northeastern Brazil with a view to identifying the main RABV host among them. Among the four species of wild canids found in the region, two (Cerdocyon thous and Pseudalopex vetulus) are frequently associated with rabies. Phylogenetic analysis of sequence data generated from mtDNA suggests that C. thous is the main wild canid host in the region. The results obtained in this study are in concordance with the zoology and ecology of wild canids, and thus, help improve epidemiologic vigilance of rabies and allow a more targeted control of the disease.
ISSN:0168-1702
1872-7492
DOI:10.1016/j.virusres.2007.08.007