Pituitary tumour pathogenesis

Pituitary adenomas are the most common tumours in the central nervous system, make up approximately 10% of all primary intracerebral tumours [1] and are found incidentally in 3–27% of autopsies [2]. The predisposition to tumour formation of the highly specialized cellular phenotypes that characteriz...

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Bibliographic Details
Published in:British medical bulletin 2005-01, Vol.75-76 (1), p.81-97
Main Author: HEANEY, Anthony P
Format: Article
Language:English
Subjects:
Adenoma - etiology
Adenoma - metabolism
Adenoma - pathology
angiogenesis
Biological and medical sciences
Cell Cycle
Cell Transformation, Neoplastic
Cyclin-Dependent Kinase Inhibitor Proteins - metabolism
General aspects
Genetic Diseases, Inborn - complications
Growth Substances - physiology
Hormones - physiology
Humans
Medical sciences
Neoplasm Proteins - physiology
oncogenes
Pituitary Neoplasms - etiology
Pituitary Neoplasms - metabolism
Pituitary Neoplasms - pathology
pituitary tumors
Securin
Signal Transduction - physiology
Transcription Factors - physiology
tumor suppressor genes
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Summary:Pituitary adenomas are the most common tumours in the central nervous system, make up approximately 10% of all primary intracerebral tumours [1] and are found incidentally in 3–27% of autopsies [2]. The predisposition to tumour formation of the highly specialized cellular phenotypes that characterize the anterior pituitary is unexplained, but it is tempting to speculate that the same hormones, growth factors and cytokines derived from intra- and extra-pituitary sites that maintain tight hypothalamic pituitary control may also contribute to pituicyte transformation. The interplay between genetic and humoural factors to promote cellular transformation is exemplified in pituitary tumorigenesis and is discussed in this review.
ISSN:0007-1420
1471-8391
DOI:10.1093/bmb/ldh062