Persistence of Vaccinia at the Site of Smallpox Vaccination

Persistence of vaccinia at vaccination sites may help determine the risk associated with secondary transmission. Culture, PCR, and antigen detection were performed on serial vaccination site swab specimens. On day 21 after vaccination, 37% of volunteers were culture positive, most of whom had receiv...

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Bibliographic Details
Published in:Clinical infectious diseases 2008-01, Vol.46 (1), p.101-102
Main Authors: Cummings, James F., Polhemus, Mark E., Hawkes, Clifton, Klote, Mary, Ludwig, George V., Wortmann, Glenn
Format: Article
Language:English
Subjects:
Biological and medical sciences
Brief Reports
Cell culture
Disease transmission
DNA polymerase
Human viral diseases
Humans
Immunization
Infectious diseases
Medical sciences
Polymerase chain reaction
Preventive medicine
Prospective Studies
Smallpox
Smallpox - prevention & control
Smallpox - virology
Smallpox Vaccine - administration & dosage
Smallpox Vaccine - adverse effects
Smallpox Vaccine - pharmacokinetics
Smallpox, monkey pox, tanapox
Tropical viral diseases
Vaccination
Vaccines
Vaccinia
Vaccinia virus
Vaccinia virus - immunology
Vaccinia virus - isolation & purification
Vaccinia virus - metabolism
Viral diseases
Viral diseases with cutaneous or mucosal lesions and viral diseases of the eye
Viruses
Volunteerism
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Summary:Persistence of vaccinia at vaccination sites may help determine the risk associated with secondary transmission. Culture, PCR, and antigen detection were performed on serial vaccination site swab specimens. On day 21 after vaccination, 37% of volunteers were culture positive, most of whom had received vaccine for the first time. Vaccinia is detectable at least through day 21 after vaccination.
ISSN:1058-4838
1537-6591
DOI:10.1086/524078