Tp53-gene transfer induces hypersensitivity to low doses of X-rays in glioblastoma cells: a strategy to convert a radio-resistant phenotype into a radiosensitive one

Tp53 is frequently mutated or inactivated in glioblastomas. Due to the impairment of p53 activity, glioblastomas show a high degree of radioresistance. In an attempt to convert the radioresistant phenotype to a more radiosensitive one, we evaluated the efficacy of the combination of Adp53 gene trans...

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Bibliographic Details
Published in:Cancer letters 2006-01, Vol.231 (1), p.102-112
Main Authors: D'Avenia, Paola, Porrello, Alessandro, Berardo, Marco, D'Angelo, Marco, Soddu, Silvia, Arcangeli, Giorgio, Sacchi, Ada, D'Orazi, Gabriella
Format: Article
Language:English
Subjects:
Adenoviridae
Adp53
Brain Neoplasms - genetics
Brain Neoplasms - pathology
Brain tumors
Cancer therapies
Cell cycle
Cell Survival
Clonogenic survival
Gene Transfer Techniques
Genes, p53
Genetic Therapy
Genotype & phenotype
Glioblastoma - genetics
Glioblastoma - pathology
Health physics
Humans
Hyper-radiosensitivity
Hypotheses
Infections
Phenotype
Polyclonal antibodies
Proteins
Radiation therapy
Radiation Tolerance
Radios
Radiotherapy
Tumor Cells, Cultured
Tumors
X-Ray Therapy
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Summary:Tp53 is frequently mutated or inactivated in glioblastomas. Due to the impairment of p53 activity, glioblastomas show a high degree of radioresistance. In an attempt to convert the radioresistant phenotype to a more radiosensitive one, we evaluated the efficacy of the combination of Adp53 gene transfer and X-ray irradiation. The combination of Adp53, at low multiplicity in order to mimic the low in vivo efficiency of virus-mediated gene delivery, with X-ray irradiation resulted in a marked decrease of glioblastoms cell survival. Interestingly, Adp53 was able to induce low dose (
ISSN:0304-3835
1872-7980
DOI:10.1016/j.canlet.2005.01.033