Mapping antigenic diversity and strain specificity of mumps virus: A bioinformatics approach

Abstract Mumps is an acute infectious disease caused by mumps virus, a member of the family Paramyxoviridae . With the implementation of vaccination programs, mumps infection is under control. However, due to resurgence of mumps epidemics, there is a renewed interest in understanding the antigenic d...

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Bibliographic Details
Published in:Virology (New York, N.Y.) N.Y.), 2007-03, Vol.359 (2), p.436-446
Main Authors: Kulkarni-Kale, Urmila, Ojha, Janaki, Manjari, G. Sunitha, Deobagkar, Deepti D, Mallya, Asha D, Dhere, Rajeev M, Kapre, Subhash V
Format: Article
Language:English
Subjects:
Antigenic Variation
Antigens, Viral - genetics
Bioinformatics
Computational Biology - methods
Conformational epitope
Genetic Speciation
Hemagglutinin–neuraminidase
Homology model
Infectious Disease
Models, Molecular
Molecular immunology
Mumps virus
Mumps virus - classification
Mumps virus - genetics
Mumps virus - immunology
Paramyxoviridae
Protein Conformation
Sequential epitope
Species Specificity
Viral Proteins - chemistry
Viral Proteins - genetics
Viral Proteins - metabolism
Wild and vaccine strain
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Summary:Abstract Mumps is an acute infectious disease caused by mumps virus, a member of the family Paramyxoviridae . With the implementation of vaccination programs, mumps infection is under control. However, due to resurgence of mumps epidemics, there is a renewed interest in understanding the antigenic diversity of mumps virus. Hemagglutinin–neuraminidase (HN) is the major surface antigen and is known to elicit neutralizing antibodies. Mutational analysis of HN of wild-type and vaccine strains revealed that the hypervariable positions are distributed over the entire length with no detectable pattern. In the absence of experimentally derived 3D structure data, the structure of HN protein of mumps virus was predicted using homology modeling. Mutations mapped on the predicted structures were found to cluster on one of the surfaces. A predicted conformational epitope encompasses experimentally characterized epitopes suggesting that it is a major site for neutralization. These analyses provide rationale for strain specificity, antigenic diversity and varying efficacy of mumps vaccines.
ISSN:0042-6822
1096-0341
DOI:10.1016/j.virol.2006.09.040