Neurodevelopmental Functioning in HIV-Infected Infants and Young Children Before and After the Introduction of Protease Inhibitor-Based Highly Active Antiretroviral Therapy

The purpose of this work was to examine the effects of HIV infection and the impact of highly active antiretroviral treatment with protease inhibitors on neurodevelopmental functioning during the first 3 years of life. Pediatric AIDS Clinical Trials Group 219/219C is a longitudinal cohort study that...

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Bibliographic Details
Published in:Pediatrics (Evanston) 2007-03, Vol.119 (3), p.e681-e693
Main Authors: Lindsey, Jane C, Malee, Kathleen M, Brouwers, Pim, Hughes, Michael D, PACTG 219C Study Team
Format: Article
Language:English
Subjects:
Age Factors
Antiretroviral Therapy, Highly Active - methods
Child Development - drug effects
Child, Preschool
Children & youth
Cognition - drug effects
Cohort Studies
Drug therapy
Effects
Female
HIV
HIV Infections - drug therapy
HIV Infections - immunology
HIV Infections - physiopathology
HIV Protease Inhibitors - therapeutic use
HIV Seronegativity - drug effects
HIV Seropositivity - drug therapy
Human immunodeficiency virus
Humans
Infant
Infant, Newborn
Longitudinal Studies
Male
Motor Activity - drug effects
Pediatrics
Prospective Studies
Protease inhibitors
Treatment Outcome
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Summary:The purpose of this work was to examine the effects of HIV infection and the impact of highly active antiretroviral treatment with protease inhibitors on neurodevelopmental functioning during the first 3 years of life. Pediatric AIDS Clinical Trials Group 219/219C is a longitudinal cohort study that has enrolled HIV-infected (HIV+) and HIV-exposed but uninfected (HIV-) infants and children since 1993. Longitudinal profiles of neurodevelopmental functioning as measured by the Bayley Scales of Infant Development were compared by HIV-infection status before and after the availability of highly active antiretroviral therapy with a protease inhibitor and within infants with Bayley tests available before and after initiating protease inhibitor therapy. In the pre-protease inhibitor era, mean mental and motor scores in HIV+ (n = 54) infants
ISSN:0031-4005
1098-4275
DOI:10.1542/peds.2006-1145