Glucocorticoid receptor polymorphisms and haplotypes associated with chronic fatigue syndrome

Chronic fatigue syndrome (CFS) is a significant public health problem of unknown etiology, the pathophysiology has not been elucidated, and there are no characteristic physical signs or laboratory abnormalities. Some studies have indicated an association of CFS with deregulation of immune functions...

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Published in:Genes, brain and behavior brain and behavior, 2007-03, Vol.6 (2), p.167-176
Main Authors: Rajeevan, M. S., Smith, A. K., Dimulescu, I., Unger, E. R., Vernon, S. D., Heim, C., Reeves, W. C.
Format: Article
Language:English
Subjects:
5' Flanking Region - genetics
Case-Control Studies
Chronic fatigue syndrome
Cohort Studies
Fatigue - classification
Fatigue - diagnosis
Fatigue - genetics
Fatigue Syndrome, Chronic - classification
Fatigue Syndrome, Chronic - diagnosis
Fatigue Syndrome, Chronic - genetics
Female
glucocorticoid receptor gene (NR3C1)
Haplotypes
Humans
hypothalamic–pituitary–adrenal axis
Lod Score
Male
Middle Aged
Polymorphism, Single Nucleotide
polymorphisms
Receptors, Glucocorticoid - genetics
Receptors, Glucocorticoid - physiology
Reference Values
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Summary:Chronic fatigue syndrome (CFS) is a significant public health problem of unknown etiology, the pathophysiology has not been elucidated, and there are no characteristic physical signs or laboratory abnormalities. Some studies have indicated an association of CFS with deregulation of immune functions and hypothalamic–pituitary–adrenal (HPA) axis activity. In this study, we examined the association of sequence variations in the glucocorticoid receptor gene (NR3C1) with CFS because NR3C1 is a major effector of the HPA axis. There were 137 study participants (40 with CFS, 55 with insufficient symptoms or fatigue, termed as ISF, and 42 non‐fatigued controls) who were clinically evaluated and identified from the general population of Wichita, KS. Nine single nucleotide polymorphisms (SNPs) in NR3C1 were tested for association of polymorphisms and haplotypes with CFS. We observed an association of multiple SNPs with chronic fatigue compared to non‐fatigued (NF) subjects (P 
ISSN:1601-1848
1601-183X
DOI:10.1111/j.1601-183X.2006.00244.x