Detection and Spread of Escherichia coli Possessing the Plasmid-Borne Carbapenemase KPC-2 in Brooklyn, New York

A carbapenem-resistant isolate of Escherichia coli was identified that possessed a 23-kb plasmid encoding Klebsiella pneumoniae carbapenemase type 2 (KPC-2). A subsequent surveillance study involving hospitals in Brooklyn, New York, revealed that, among 1417 E. coli isolates, 7 isolates (from 3 hosp...

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Bibliographic Details
Published in:Clinical infectious diseases 2007-04, Vol.44 (7), p.972-975
Main Authors: Bratu, Simona, Brooks, Steven, Burney, Sibte, Kochar, Sandeep, Gupta, Jyoti, Landman, David, Quale, John
Format: Article
Language:English
Subjects:
Aged
Anti-Bacterial Agents - pharmacology
Anti-Bacterial Agents - therapeutic use
Antibiotics
Antimicrobials
Bacterial Proteins - metabolism
beta-Lactamases - metabolism
Biological and medical sciences
Brief Reports
Carbapenems
Carbapenems - pharmacology
Cross Infection - epidemiology
Cross Infection - microbiology
Disease Outbreaks
DNA
Drug resistance
Drug Resistance, Bacterial
E coli
Enzymes
Escherichia coli
Escherichia coli - classification
Escherichia coli - enzymology
Escherichia coli Infections - diagnosis
Escherichia coli Infections - epidemiology
Humans
Incidence
Infectious diseases
Klebsiella pneumoniae
Male
Medical sciences
Microbial Sensitivity Tests
New York City - epidemiology
Plasmids
Polymerase Chain Reaction
Population Surveillance
Studies
Surveillance
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Summary:A carbapenem-resistant isolate of Escherichia coli was identified that possessed a 23-kb plasmid encoding Klebsiella pneumoniae carbapenemase type 2 (KPC-2). A subsequent surveillance study involving hospitals in Brooklyn, New York, revealed that, among 1417 E. coli isolates, 7 isolates (from 3 hospitals) possessed blaKPC-2. E. coli possessing KPC-2 is emerging in our region, and improved methods for detection are urgently needed.
ISSN:1058-4838
1537-6591
DOI:10.1086/512370