A Helical PTFE Arteriovenous Access Graft to Swirl Flow Across the Distal Anastomosis: Results of a Preliminary Clinical Study

Intimal hyperplasia develops preferentially in regions where the blood flow is stagnant and wall shear stress low. The small amplitude helical geometry of the SwirlGraft™ was designed to ensure physiological-type swirling flow, and thus suppress the triggers. We report the first conceptual testing o...

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Bibliographic Details
Published in:European journal of vascular and endovascular surgery 2007-04, Vol.33 (4), p.472-475
Main Authors: Huijbregts, H.J.T.A.M, Blankestijn, P.J, Caro, C.G, Cheshire, N.J.W, Hoedt, M.T.C, Tutein Nolthenius, R.P, Moll, F.L
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Angiography
Arm - blood supply
Arteriovenous Shunt, Surgical - adverse effects
Arteriovenous Shunt, Surgical - instrumentation
Blood Vessel Prosthesis Implantation - adverse effects
Blood Vessel Prosthesis Implantation - instrumentation
Constriction, Pathologic - etiology
Europe
Female
Follow-Up Studies
Helical geometry
Hemodialysis
Humans
Male
Middle Aged
Patency
Pilot Projects
Polytetrafluoroethylene
Prospective Studies
Prosthesis Design
PTFE
Regional Blood Flow
Renal Dialysis - methods
Surgery
Swirl
Thrombosis - etiology
Time Factors
Treatment Outcome
Vascular access
Vascular Patency
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Summary:Intimal hyperplasia develops preferentially in regions where the blood flow is stagnant and wall shear stress low. The small amplitude helical geometry of the SwirlGraft™ was designed to ensure physiological-type swirling flow, and thus suppress the triggers. We report the first conceptual testing of the SwirlGraft™. Primary, assisted primary and secondary patency rates at 6 months in 20 patients were 57.9 ± 11.4%, 84.4 ± 8.3% and 100 ± 0.0%. There was angiographic evidence of reduction of helical geometry in a proportion of the grafts. The helical graft is associated with high assisted primary and secondary patency. Elaboration of the surgical implantation techniques and an improved SwirlGraft™ design can be expected to exploit the advantages of the helical concept.
ISSN:1078-5884
1532-2165
DOI:10.1016/j.ejvs.2006.10.028