Functions of Paracrine PDGF Signaling in the Proangiogenic Tumor Stroma Revealed by Pharmacological Targeting

Important support functions, including promotion of tumor growth, angiogenesis, and invasion, have been attributed to the different cell types populating the tumor stroma, i.e., endothelial cells, cancer-associated fibroblasts, pericytes, and infiltrating inflammatory cells. Fibroblasts have long be...

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Bibliographic Details
Published in:	PLoS medicine 2008-01, Vol.5 (1), p.e19-e19
Main Authors:	Pietras, Kristian, Pahler, Jessica, Bergers, Gabriele, Hanahan, Douglas
Format:	Article
Language:	English
Subjects:	Animals Antineoplastic Agents - pharmacology Antineoplastic Agents - therapeutic use Benzamides Cancer: Gynecological Carcinoma - blood supply Carcinoma - drug therapy Carcinoma - physiopathology Carcinoma - virology Cervical cancer Chemotherapy Epithelial Cells - metabolism Estradiol - administration & dosage Estradiol - toxicity Female Fibroblast Growth Factor 2 - biosynthesis Fibroblast Growth Factor 2 - genetics Fibroblast Growth Factor 2 - physiology Fibroblast Growth Factor 7 - biosynthesis Fibroblast Growth Factor 7 - genetics Fibroblast Growth Factor 7 - physiology Fibroblasts - drug effects Fibroblasts - enzymology Fibroblasts - secretion Human papillomavirus Human papillomavirus 16 Humans Imatinib Mesylate Medical research Mice Mice, Inbred Strains Mice, Transgenic Neoplasm Proteins - antagonists & inhibitors Neoplasm Proteins - biosynthesis Neoplasm Proteins - genetics Neoplasm Proteins - physiology Neovascularization, Pathologic - drug therapy Neovascularization, Pathologic - physiopathology Oncology Paracrine Communication - drug effects Paracrine Communication - physiology Pericytes - metabolism Piperazines - pharmacology Piperazines - therapeutic use Platelet-Derived Growth Factor - antagonists & inhibitors Platelet-Derived Growth Factor - genetics Platelet-Derived Growth Factor - physiology Protein Kinase Inhibitors - pharmacology Protein Kinase Inhibitors - therapeutic use Proteins Proto-Oncogene Proteins c-kit - biosynthesis Proto-Oncogene Proteins c-kit - genetics Pyrimidines - pharmacology Pyrimidines - therapeutic use Receptors, Platelet-Derived Growth Factor - antagonists & inhibitors Receptors, Platelet-Derived Growth Factor - genetics Receptors, Platelet-Derived Growth Factor - physiology Stromal Cells - drug effects Stromal Cells - enzymology Stromal Cells - secretion Tumors Uterine Cervical Neoplasms - blood supply Uterine Cervical Neoplasms - drug therapy Uterine Cervical Neoplasms - physiopathology Uterine Cervical Neoplasms - virology
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