Microinfusion into the rat brain of antibodies against Semliki Forest Virus produces changes in behavioral response to apomorphine

Abstract Anti-SFV antibodies generated during SFV infection may affect CNS function due to cross-reactivity with a peptide of oligodendrocyte myelin glycoprotein. To explore this possibility, total IgG from SFV immunized or normal control rabbits was unilaterally microinfused into the subthalamic re...

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Bibliographic Details
Published in:Journal of neuroimmunology 2007-03, Vol.184 (1), p.149-155
Main Authors: Knopf, Paul M, Harling-Berg, Christine J, Lee, Darrin J, Hallett, Joseph J, Stopa, Edward G, Mokhtarian, Foroozan
Format: Article
Language:English
Subjects:
Allergy and Immunology
Animals
Antibodies - pharmacology
Apomorphine - pharmacology
Apomorphine-stimulated rotation assay (ASRA)
Basal ganglia
Behavior, Animal - drug effects
Brain - drug effects
Brain cross-reactive antibodies
Dopamine Agonists - pharmacology
Enzyme-Linked Immunosorbent Assay - methods
Male
Molecular mimicry
Motor Activity - drug effects
Multiple sclerosis
Neurology
Neuronal dysfunction
Rats
Rats, Inbred F344
Rotarod Performance Test
Semliki Forest virus
Semliki Forest Virus (SFV)
Semliki forest virus - chemistry
Subthalamic nucleus
Time Factors
Viral Proteins - immunology
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Summary:Abstract Anti-SFV antibodies generated during SFV infection may affect CNS function due to cross-reactivity with a peptide of oligodendrocyte myelin glycoprotein. To explore this possibility, total IgG from SFV immunized or normal control rabbits was unilaterally microinfused into the subthalamic region of normal rat brain. Behavior of the IgG-infused rats was determined using a bioassay, measuring rotational locomotion following systemic injection of apomorphine. Anti-SFV IgG-infused rats demonstrated a significantly increased ( p < 0.005) ipsilateral turning response compared to control rats, persisting for at least a month. Results suggest that brain cross-reactive antibodies in anti-SFV IgG may affect brain function.
ISSN:0165-5728
1872-8421
DOI:10.1016/j.jneuroim.2006.12.004