Changes in brain oxidative metabolism induced by water maze training

Abstract Although the hippocampus has been shown to be essential for spatial memory, the contribution of associated brain regions is not well established. Wistar rats were trained to find a hidden escape platform in the water maze during eight days. Following training, the oxidative metabolism in di...

Full description

Saved in:
Bibliographic Details
Published in:Neuroscience 2007-03, Vol.145 (2), p.403-412
Main Authors: Conejo, N.M, González-Pardo, H, Vallejo, G, Arias, J.L
Format: Article
Language:English
Subjects:
Animals
Anterior Thalamic Nuclei - anatomy & histology
Anterior Thalamic Nuclei - metabolism
Biological and medical sciences
Brain - anatomy & histology
Brain - metabolism
Electron Transport Complex IV - analysis
Electron Transport Complex IV - metabolism
Energy Metabolism - physiology
Fundamental and applied biological sciences. Psychology
Hippocampus - anatomy & histology
Hippocampus - metabolism
limbic system
Male
Maze Learning - physiology
Memory - physiology
Neural Pathways - anatomy & histology
Neural Pathways - metabolism
Neurology
oxidative metabolism
Oxidative Phosphorylation
Prefrontal Cortex - anatomy & histology
Prefrontal Cortex - metabolism
rat
Rats
Rats, Wistar
spatial memory
Up-Regulation - physiology
Vertebrates: nervous system and sense organs
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Abstract Although the hippocampus has been shown to be essential for spatial memory, the contribution of associated brain regions is not well established. Wistar rats were trained to find a hidden escape platform in the water maze during eight days. Following training, the oxidative metabolism in different brain regions was evaluated using cytochrome oxidase histochemistry. Metabolic activations were found in the prelimbic cortex, cornu ammonis (CA) 1 subfield of the dorsal hippocampus and the anterior thalamic nuclei, relative to yoked swim controls and naïve rats. In addition, many cross-correlations in brain metabolism were observed among the latter regions. These results support the implication of a hippocampal–prefrontal–thalamic system to spatial memory in rats.
ISSN:0306-4522
1873-7544
DOI:10.1016/j.neuroscience.2006.11.057