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Integrin signaling is integral to regeneration
The inability of the adult injured mammalian spinal cord to successfully regenerate is not well understood. Studies suggest that both extrinsic and intrinsic factors contribute to regeneration failure. In this review, we focus on intrinsic factors that impact regeneration, in particular integrin rec...
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| Published in: | Experimental neurology 2008-02, Vol.209 (2), p.343-352 |
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| Main Authors: | , |
| Format: | Article |
| Language: | English |
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| container_end_page | 352 |
| container_issue | 2 |
| container_start_page | 343 |
| container_title | Experimental neurology |
| container_volume | 209 |
| creator | Lemons, Michele L. Condic, Maureen L. |
| description | The inability of the adult injured mammalian spinal cord to successfully regenerate is not well understood. Studies suggest that both extrinsic and intrinsic factors contribute to regeneration failure. In this review, we focus on intrinsic factors that impact regeneration, in particular integrin receptors and their downstream signaling pathways. We discuss studies that address the impact of integrins and integrin signaling pathways on growth cone guidance and motility and how lessons learned from these studies apply to spinal cord regeneration
in vivo. |
| doi_str_mv | 10.1016/j.expneurol.2007.05.027 |
| format | article |
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| fulltext | fulltext |
| identifier | ISSN: 0014-4886 |
| ispartof | Experimental neurology, 2008-02, Vol.209 (2), p.343-352 |
| issn | 0014-4886 1090-2430 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_70263219 |
| source | Elsevier |
| subjects | Animals Chondroitin sulfate proteoglycans CSPGs FAK Gene Expression Regulation - physiology Growth cone Guidance Humans Integrin receptors Integrins - physiology Models, Biological Motility Nerve Regeneration - physiology Rac Rho and Ras GTPase Semaphorin Signal Transduction - physiology Spinal Cord Injuries - physiopathology |
| title | Integrin signaling is integral to regeneration |
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