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Homocysteine is a potent modulator of plasma membrane electron transport systems

The deregulation of homocysteine metabolism leads to hyperhomocysteinemia, a condition described as an independent cardiovascular disease risk factor. Ubiquitous plasma membrane redox systems can play a dual pro-oxidant and anti-oxidant role in defense. In this study, we test the hypothesis that hom...

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Published in:	Journal of bioenergetics and biomembranes 2008-02, Vol.40 (1), p.45-51
Main Authors:	Rodríguez-Alonso, Javier, Montañez, Raúl, Rodríguez-Caso, Luis, Medina, Miguel Ángel
Format:	Article
Language:	English
Subjects:	Animal Anatomy Animal Biochemistry Animals Antineoplastic Agents - pharmacology Biochemistry Bioenergetics Bioorganic Chemistry Cancer Cardiovascular diseases Cardiovascular Diseases - etiology Cardiovascular Diseases - metabolism Cardiovascular Diseases - pathology Cattle Cell Line, Tumor Cell Membrane - metabolism Cell Membrane - pathology Chemistry Chemistry and Materials Science Deregulation Electron Transport - drug effects Electrons Endothelium, Vascular - metabolism Endothelium, Vascular - pathology Enzymes Health risks Histology Homocysteine Homocysteine - pharmacology Humans Hyperhomocysteinemia - complications Hyperhomocysteinemia - metabolism Hyperhomocysteinemia - pathology Membranes Morphology NADPH Oxidases - metabolism Neoplasm Proteins - metabolism Neoplasms - drug therapy Neoplasms - enzymology Organic Chemistry Oxidation-Reduction - drug effects Oxidizing agents Plasma Risk Factors
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container_title	Journal of bioenergetics and biomembranes
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creator	Rodríguez-Alonso, Javier Montañez, Raúl Rodríguez-Caso, Luis Medina, Miguel Ángel
description	The deregulation of homocysteine metabolism leads to hyperhomocysteinemia, a condition described as an independent cardiovascular disease risk factor. Ubiquitous plasma membrane redox systems can play a dual pro-oxidant and anti-oxidant role in defense. In this study, we test the hypothesis that homocysteine, as a redox active compound, could modulate the endothelial plasma membrane redox system. We show that homocysteine behaves as a very potent stimulator of this activity. Furthermore, we show that this inducing effect is also produced on tumor cells and that it can be observed at both the activity and protein levels. On the other hand, homocysteine treatment decreases the activity of the specific ectocellular tumor NADH oxidase. Taken together, these results underscore a potential antitumoral action of homocysteine.
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subjects	Animal Anatomy Animal Biochemistry Animals Antineoplastic Agents - pharmacology Biochemistry Bioenergetics Bioorganic Chemistry Cancer Cardiovascular diseases Cardiovascular Diseases - etiology Cardiovascular Diseases - metabolism Cardiovascular Diseases - pathology Cattle Cell Line, Tumor Cell Membrane - metabolism Cell Membrane - pathology Chemistry Chemistry and Materials Science Deregulation Electron Transport - drug effects Electrons Endothelium, Vascular - metabolism Endothelium, Vascular - pathology Enzymes Health risks Histology Homocysteine Homocysteine - pharmacology Humans Hyperhomocysteinemia - complications Hyperhomocysteinemia - metabolism Hyperhomocysteinemia - pathology Membranes Morphology NADPH Oxidases - metabolism Neoplasm Proteins - metabolism Neoplasms - drug therapy Neoplasms - enzymology Organic Chemistry Oxidation-Reduction - drug effects Oxidizing agents Plasma Risk Factors
title	Homocysteine is a potent modulator of plasma membrane electron transport systems
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