Plasma S100A12 Concentrations in Peritoneal Dialysis Patients and Subclinical Chronic Inflammatory Disease

• Published in: Therapeutic apheresis and dialysis 2008-02, Vol.12 (1), p.28-32
• Main Authors: Uchiyama-Tanaka, Yoko, Mori, Yasukiyo, Kosaki, Atsushi, Kimura, Tatsuji, Moriishi, Misaki, Kawanishi, Hideki, Matsubara, Hiroaki
• Format: Article
• Language: English
• Subjects: Adult; Advanced glycation end products; Atherosclerosis; Biological Transport; Chronic Disease; Enzyme-Linked Immunosorbent Assay - methods; Female; Humans; Inflammation - physiopathology; Male; Middle Aged; Peritoneal dialysis; Peritoneal Dialysis, Continuous Ambulatory; Peritoneal Diseases - physiopathology; Peritoneal transport; S100 Proteins - blood; S100A12; S100A12 Protein; Sclerosis - physiopathology
• ISSN: 1744-9979; 1744-9987
• DOI: 10.1111/j.1744-9987.2007.00537.x

:  S100A12 is a ligand for the receptor for advanced glycation end products. It has been shown that S100A12 induces expression of adhesion molecules, and mediates activation and migration of monocytes/macrophages. Circulating S100A12 may be involved in chronic inflammation. We previously reported increased S100A12 levels in patients with non‐insulin‐dependent diabetes mellitus and hemodialysis. A high peritoneal solute transport rate may be associated with encapsulating peritoneal sclerosis and mortality. We measured plasma S100A12 levels in peritoneal dialysis patients and evaluated a possible relation between the increased plasma S100A12 levels in peritoneal dialysis patients and the high peritoneal solute transport rate. Subjects included 36 patients (mean age ± SE, 46.0 ± 12.0 years) with no apparent infection and no malignancy who had been undergoing peritoneal dialysis for 36.5 ± 3.9 months. We developed an enzyme‐linked immunosorbent assay system to measure plasma S100A12 levels. A peritoneal equilibrium test was performed and subjects were categorized as high and high‐average (H) (n = 14) or low and low‐average (L) (n = 22) transporters. Plasma S100A12 concentrations were significantly higher in peritoneal dialysis patients (21.6 ± 3.0 ng/mL) than in control subjects (n = 42; 10.8 ± 1.0 ng/mL). Plasma S100A12 concentrations were also higher in the H group (28.2 ± 6.1 ng/mL) than in the L group (14.2 ± 2.0 ng/mL). These results suggest that S100A12 may be a sensitive marker of subclinical inflammation and that an increased S100A12 level may be related to the high peritoneal solute transport rate.