Worse Renal Transplant Outcomes Observed Among Afro-Brazilian Patients on Prospective Registry Data of 2461 Renal Transplants at Least 1 Year Follow-up

Abstract We present prospective registry data of 2461 (live donor = 1753 and deceased donor = 08) renal transplants performed between 1999 and 2003. All subjects were followed for more than 1 year after transplantation and most were treated with a calcineurin inhibitor and azathioprine. Afro-Brazili...

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Bibliographic Details
Published in:Transplantation proceedings 2007-03, Vol.39 (2), p.435-436, Article 435
Main Authors: Medina-Pestana, J.O, Sampaio, E.M, Vaz, M.L.S, Pinheiro-Machado, P.G, Tedesco-Silva, H
Format: Article
Language:English
Subjects:
Adult
Africa - ethnology
Biological and medical sciences
Brazil - epidemiology
Cadaver
Epidemiology
Female
Follow-Up Studies
Fundamental and applied biological sciences. Psychology
Fundamental immunology
General aspects
Graft Survival - physiology
Humans
Kidney Transplantation - mortality
Kidney Transplantation - pathology
Kidney Transplantation - physiology
Kidney Transplantation - statistics & numerical data
Living Donors
Male
Medical sciences
Middle Aged
Prospective Studies
Public health. Hygiene
Public health. Hygiene-occupational medicine
Registries
Surgery
Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases
Survival Analysis
Time Factors
Tissue Donors
Tissue, organ and graft immunology
Treatment Failure
Treatment Outcome
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Summary:Abstract We present prospective registry data of 2461 (live donor = 1753 and deceased donor = 08) renal transplants performed between 1999 and 2003. All subjects were followed for more than 1 year after transplantation and most were treated with a calcineurin inhibitor and azathioprine. Afro-Brazilian, white, and mixed patients constituted 11% (272), 67.1% (1651), and 14.9% (367) of the population respectively. Mean dialysis time was 42.3 ± 32.9 months and delayed graft function, occurred in more than 60%. Three-year patient survival rates were 96.3%, 92.8%, and 86.7% for living-related, living-unrelated, and deceased donors, respectively. Corresponding 3-year graft survival rates were 87.3%, 82.1%, and 71.3% and functional graft survival rates were 90.2%, 88.8%, and 81.5%. The poorer transplant outcome observed among Afro-Brazilian patients has been mainly attributed to differences in absorption of cyclosporine, tacrolimus, and mycophenolate mofetil.
ISSN:0041-1345
1873-2623
DOI:10.1016/j.transproceed.2007.01.034