Worse Renal Transplant Outcomes Observed Among Afro-Brazilian Patients on Prospective Registry Data of 2461 Renal Transplants at Least 1 Year Follow-up

• Published in: Transplantation proceedings 2007-03, Vol.39 (2), p.435-436, Article 435
• Main Authors: Medina-Pestana, J.O, Sampaio, E.M, Vaz, M.L.S, Pinheiro-Machado, P.G, Tedesco-Silva, H
• Format: Article
• Language: English
• Subjects: Adult; Africa - ethnology; Biological and medical sciences; Brazil - epidemiology; Cadaver; Epidemiology; Female; Follow-Up Studies; Fundamental and applied biological sciences. Psychology; Fundamental immunology; General aspects; Graft Survival - physiology; Humans; Kidney Transplantation - mortality; Kidney Transplantation - pathology; Kidney Transplantation - physiology; Kidney Transplantation - statistics & numerical data; Living Donors; Male; Medical sciences; Middle Aged; Prospective Studies; Public health. Hygiene; Public health. Hygiene-occupational medicine; Registries; Surgery; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases; Survival Analysis; Time Factors; Tissue Donors; Tissue, organ and graft immunology; Treatment Failure; Treatment Outcome
• ISSN: 0041-1345; 1873-2623
• DOI: 10.1016/j.transproceed.2007.01.034

Abstract We present prospective registry data of 2461 (live donor = 1753 and deceased donor = 08) renal transplants performed between 1999 and 2003. All subjects were followed for more than 1 year after transplantation and most were treated with a calcineurin inhibitor and azathioprine. Afro-Brazilian, white, and mixed patients constituted 11% (272), 67.1% (1651), and 14.9% (367) of the population respectively. Mean dialysis time was 42.3 ± 32.9 months and delayed graft function, occurred in more than 60%. Three-year patient survival rates were 96.3%, 92.8%, and 86.7% for living-related, living-unrelated, and deceased donors, respectively. Corresponding 3-year graft survival rates were 87.3%, 82.1%, and 71.3% and functional graft survival rates were 90.2%, 88.8%, and 81.5%. The poorer transplant outcome observed among Afro-Brazilian patients has been mainly attributed to differences in absorption of cyclosporine, tacrolimus, and mycophenolate mofetil.