The use of adjuvant granulocyte-macrophage colony-stimulating factor in HIV-related disseminated atypical mycobacterial infection

Summary Mycobacterium avium complex (MAC) continues to be a challenging problem in some patients with advanced human immunodeficiency virus (HIV) infection despite the availability of potent chemotherapeutic agents. The use of adjunctive immunomodulatory therapy has shown promise in vitro, but there...

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Bibliographic Details
Published in:The Journal of infection 2007-04, Vol.54 (4), p.e207-e210
Main Authors: de Silva, T.I, Cope, A, Goepel, J, Greig, J.M
Format: Article
Language:English
Subjects:
Adjuvants, Immunologic - pharmacology
Adjuvants, Immunologic - therapeutic use
AIDS-Related Opportunistic Infections - immunology
AIDS-Related Opportunistic Infections - microbiology
AIDS-Related Opportunistic Infections - therapy
GM-CSF
Granulocyte-Macrophage Colony-Stimulating Factor - pharmacology
Granulocyte-Macrophage Colony-Stimulating Factor - therapeutic use
HIV
HIV Infections - complications
HIV Infections - immunology
HIV-1
Human immunodeficiency virus
Humans
Infectious Disease
Macrophages - drug effects
Macrophages - microbiology
Male
Middle Aged
Mycobacteria
Mycobacterium avium
Mycobacterium avium Complex - drug effects
Mycobacterium avium-intracellulare Infection - immunology
Mycobacterium avium-intracellulare Infection - microbiology
Mycobacterium avium-intracellulare Infection - therapy
Treatment Outcome
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Summary:Summary Mycobacterium avium complex (MAC) continues to be a challenging problem in some patients with advanced human immunodeficiency virus (HIV) infection despite the availability of potent chemotherapeutic agents. The use of adjunctive immunomodulatory therapy has shown promise in vitro, but there is currently limited supportive clinical evidence [Kemper CA, Bermudez LE, Derenski SC. Immunomodulatory treatment of Mycobacterium avium complex bacteraemia in patients with AIDS by use of recombinant granulocyte-macrophage colony-stimulating factor. J Infect Dis 1998; 177 :914–20; Kedzierska K, Johnson M, Mijch A, Cooke I, Rainbird M, Roberts S, et al. Granulocyte-macrophage colony-stimulating factor augments phagocytosis of Mycobacterium avium complex by human immunodeficiency virus type-1 infected monocytes/macrophages in vitro and in vivo. J Infect Dis 2000; 181 :390–94]. We report the resolution of MAC disease resistant to traditional therapy, in an HIV-infected individual, following the addition of granulocyte-macrophage colony-stimulating factor (GM-CSF).
ISSN:0163-4453
1532-2742
DOI:10.1016/j.jinf.2006.11.005