Share Epitope, Citrullinated Cyclic Peptide Antibodies and Smoking in Brazilian Rheumatoid Arthritis Patients

The events involved in the pathogenesis of rheumatoid arthritis (RA) still remain unclear, but certainly the etiology is multifactorial. Shared epitope (SE) of HLADRβ1 is the most important genetic risk factor. Environmental risk factors are less understood. Smoking is a candidate, associated with t...

Full description

Saved in:
Bibliographic Details
Published in:Clinical reviews in allergy & immunology 2008-02, Vol.34 (1), p.32-35
Main Authors: Oliveira, Rene Donizeti, Junta, Cristina Maria, Oliveira, Fabíola Reis, Silva, Lucienir Maria, Donadi, Eduardo Antonio, Louzada-Junior, Paulo
Format: Article
Language:English
Subjects:
Adult
Aged
Allergology
Arthritis, Rheumatoid - diagnosis
Arthritis, Rheumatoid - genetics
Arthritis, Rheumatoid - immunology
Autoantibodies - blood
Brazil
Epitopes - immunology
Female
Health risk assessment
HLA-DR Antigens - genetics
HLA-DR Antigens - immunology
HLA-DRB1 Chains
Humans
Immunology
Internal Medicine
Male
Medical research
Medicine
Medicine & Public Health
Middle Aged
Nephelometry and Turbidimetry
Peptides, Cyclic - immunology
Rheumatoid arthritis
Smoking
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The events involved in the pathogenesis of rheumatoid arthritis (RA) still remain unclear, but certainly the etiology is multifactorial. Shared epitope (SE) of HLADRβ1 is the most important genetic risk factor. Environmental risk factors are less understood. Smoking is a candidate, associated with the rising of citrullinated cyclic peptide antibodies (anti-CCP). Anti-CCP antibodies are highly specific for RA. In this study, we investigated whether the association between anti-CCP production and smoking was influenced by carriage of SE in a highly miscegenated population of patients with RA. One hundred Brazilian patients were inquired about cigarette smoking. For all of them, DNA for HLA typing and serum to anti-CCP antibodies quantification were obtained. Forty-two were smokers and 58 were nonsmokers. The SE was present in 61 patients and the anti-CCP was positive in 71 patients. We found that, among smokers, 25 were SE-positive, 22 presented with anti-CCP and 3 without anti-CCP, and 17 were SE-negative, 9 presented with anti-CCP and 8 without anti-CCP (OR 6.5, 95% CI 1.40 to 30.20). These results suggest that environmental factors contribute to the raising of anti-CCP in individuals with HLA background to RA, smoking being a strong candidate.
ISSN:1080-0549
1559-0267
DOI:10.1007/s12016-007-8017-2