Meta-regression analysis using latitude as moderator of paternal age related schizophrenia risk: High ambient temperature induced de novo mutations or is it related to the cold?

AbstractWhile the season of birth, latitude and first admission effects suggest higher risk of schizophrenia with cold climate, the high ambient temperature induced de novo mutation hypothesis suggests the opposite. We conducted a systematic review and meta-analysis (4 case-control studies and 5 coh...

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Bibliographic Details
Published in:Schizophrenia research 2008-02, Vol.99 (1), p.71-76
Main Authors: Cheng, Jackie Y.W, Ko, John S.N, Chen, Ronald Y.L, Ng, Emil M.L
Format: Article
Language:English
Subjects:
Adult and adolescent clinical studies
Biological and medical sciences
Case-Control Studies
Cohort Studies
Cold Climate - adverse effects
Cross-Sectional Studies
Female
Hot Temperature - adverse effects
Humans
Latitude
Medical sciences
Meta-analysis
Meta-regression
Mutation - genetics
Paternal Age
Pregnancy
Prenatal Exposure Delayed Effects
Psychiatric/Mental Health
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Psychoses
Regression Analysis
Risk Factors
Schizophrenia
Schizophrenia - epidemiology
Schizophrenia - genetics
Seasons
Temperature
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Summary:AbstractWhile the season of birth, latitude and first admission effects suggest higher risk of schizophrenia with cold climate, the high ambient temperature induced de novo mutation hypothesis suggests the opposite. We conducted a systematic review and meta-analysis (4 case-control studies and 5 cohort studies). We used annual mean daily temperature and latitude of study sites as direct and indirect measures of ambient temperature respectively. Using case-control studies conducted in the Northern hemisphere for meta-regression, high latitude and low ambient temperature were found to increase paternal age related schizophrenia risk significantly. More research is needed to support the de novo mutation hypothesis.
ISSN:0920-9964
1573-2509
DOI:10.1016/j.schres.2007.10.016