Resveratrol modulates roscovitine-mediated cell cycle arrest of human MCF-7 breast cancer cells

Human MCF-7 breast cancer cells are relatively resistant to anti-cancer drugs. Recently, we reported that roscovitine (ROSC), a selective cyclin-dependent kinase (CDK) inhibitor, arrested human MCF-7 breast cancer cells in G 2 phase of the cell cycle and concomitantly induced apoptosis. Moreover, we...

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Published in:	Food and chemical toxicology 2008-04, Vol.46 (4), p.1327-1333
Main Authors:	Węsierska-Gądek, Józefa, Kramer, Matthias P., Maurer, Margarita
Format:	Article
Language:	English
Subjects:	antineoplastic agents Antineoplastic Agents - pharmacology Antioxidants Antioxidants - pharmacology apoptosis Biological and medical sciences biosynthesis breast neoplasms Breast Neoplasms - drug therapy Breast Neoplasms - pathology CDK-inhibitors Cell Count cell cycle Cell Cycle - drug effects Cell cycle block Cell Line, Tumor cell proliferation Cell Proliferation - drug effects Cell Survival Cell Survival - drug effects Chemosensitization cyclin-dependent kinase inhibitor cytotoxicity DNA DNA - biosynthesis DNA - genetics drug effects drug therapy enzyme inhibitors Estrogen receptor Female Flow Cytometry genetics Gynecology. Andrology. Obstetrics human diseases human nutrition Humans kinases Mammary gland diseases Medical sciences p53 tumor suppressor pathology pharmacology phosphotransferases (kinases) Plant poisons toxicology Polyphenols Purines Purines - pharmacology resveratrol Stilbenes Stilbenes - pharmacology synergism Toxicology Tumors
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