On the design of national vaccination programmes

Abstract The decision to include a vaccine in a national vaccination programme (or not) is usually evidence-based. Thereby, it is essential that the target disease causes a high burden of disease and that vaccination reduces this burden considerably. Furthermore, vaccination should be considered to...

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Bibliographic Details
Published in:Vaccine 2007-04, Vol.25 (16), p.3143-3145
Main Authors: van der Zeijst, B.A.M, Dijkman, M.I, Luytjes, W, van Alphen, A.J.W, van den Dobbelsteen, G.P.J.M
Format: Article
Language:English
Subjects:
Age
Allergy and Immunology
Applied microbiology
Biological and medical sciences
Bordetella pertussis
Clinical trials
Correlates of protection
Disease
Fundamental and applied biological sciences. Psychology
Haemophilus influenzae
Health Policy
Hepatitis
Humans
Immunisation programme
Immunization Programs - methods
Licenses
Meningitis
Microbiology
Tetanus
Vaccination - economics
Vaccination - standards
Vaccination schedule
Vaccines
Vaccines - administration & dosage
Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)
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Summary:Abstract The decision to include a vaccine in a national vaccination programme (or not) is usually evidence-based. Thereby, it is essential that the target disease causes a high burden of disease and that vaccination reduces this burden considerably. Furthermore, vaccination should be considered to be cost-effective by a government. Vaccines are usually administered according to standard vaccination schedules, which have been established on historical grounds. We argue and demonstrate with examples (meningococci C, Haemophilus influenzae , pneumococci and Bordetella pertussis ) that adaptation of these standard vaccination schedules can be cost-saving and lead to better protection. To facilitate the improvement of vaccination programmes, a better understanding of protective immune responses (correlates of protection) and immunologic memory are required.
ISSN:0264-410X
1873-2518
DOI:10.1016/j.vaccine.2007.01.076