Calcific aortic valve disease should not be considered as a degenerative disease anymore

Summary Calcific aortic valve disease is common among the elderly. Until recently, the concept that calcific aortic valve disease is a degenerative and unmodifiable process basically induced by long-lasting mechanical stress was generally accepted. However calcific aortic valve disease is not merely...

Full description

Saved in:
Bibliographic Details
Published in:Medical hypotheses 2007-01, Vol.68 (6), p.1233-1235
Main Authors: Li, Yan Bo, Hu, Cheng Lin, Liu, Jun, Tang, Qi Zhu, Huang, Cong Xin
Format: Article
Language:English
Subjects:
Aged
Angiotensin-Converting Enzyme Inhibitors - therapeutic use
Aortic Valve - pathology
Calcinosis - etiology
Calcinosis - pathology
Heart Valve Diseases - etiology
Heart Valve Diseases - pathology
Humans
Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use
Internal Medicine
Models, Cardiovascular
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Summary Calcific aortic valve disease is common among the elderly. Until recently, the concept that calcific aortic valve disease is a degenerative and unmodifiable process basically induced by long-lasting mechanical stress was generally accepted. However calcific aortic valve disease is not merely related to age-associated “wear and tear”. The development and progression of calcific aortic valve disease are based on an active process that shares a number of similarities with atherosclerosis. Statins and angiotensin-converting enzyme inhibitors have been shown to slow calcium accumulation in aortic valves. Thus, calcific aortic valve disease should not be considered as a degenerative disease anymore.
ISSN:0306-9877
1532-2777
DOI:10.1016/j.mehy.2006.07.049