Is there a benefit from intensified medical and psychological interventions in patients with functional dyspepsia not responding to conventional therapy?

SUMMARY Aim In a prospective randomized, controlled trial, to compare the long‐term outcome of intensive medical therapy (with or without cognitive‐behavioural or muscle relaxation therapy) vs. standard medical therapy in patients with refractory functional dyspepsia (FD), referred to a tertiary ref...

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Bibliographic Details
Published in:Alimentary pharmacology & therapeutics 2007-04, Vol.25 (8), p.973-986
Main Authors: HAAG, S., SENF, W., TAGAY, S., LANGKAFEL, M., BRAUN‐LANG, U., PIETSCH, A., HEUFT, G., TALLEY, N. J., HOLTMANN, G.
Format: Article
Language:English
Subjects:
Adult
Anti-Ulcer Agents - therapeutic use
Antidepressive Agents - therapeutic use
Anxiety - etiology
Biological and medical sciences
Cognitive Therapy - methods
Depressive Disorder - etiology
Digestive system
Dyspepsia - psychology
Dyspepsia - therapy
Female
Gastroenterology. Liver. Pancreas. Abdomen
Humans
Medical sciences
Middle Aged
Other diseases. Semiology
Patient Dropouts
Pharmacology. Drug treatments
Quality of Life - psychology
Relaxation Therapy
Stomach. Duodenum. Small intestine. Colon. Rectum. Anus
Treatment Outcome
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Summary:SUMMARY Aim In a prospective randomized, controlled trial, to compare the long‐term outcome of intensive medical therapy (with or without cognitive‐behavioural or muscle relaxation therapy) vs. standard medical therapy in patients with refractory functional dyspepsia (FD), referred to a tertiary referral medical center. Methods A total of 100 consecutive FD patients were allocated to a standardized symptom‐oriented 4 month therapy (SMT, n = 24), intensive medical therapy (IMT, medical therapy with testing‐for and targeting‐of abnormalities of motor‐and‐sensory function, n = 28) or IMT plus psychological interventions (either progressive‐muscle relaxation (IMT‐MR, n = 20) or cognitive‐behavioural therapy (IMT‐CBT, n = 28). The symptom intensity (SI) and health‐related quality‐of‐life (HRQoL) after 12 months were prespecified primary outcome parameters. Results After 12 months, significantly greater improvement of SI occurred in patients with IMT‐all (with or without psychological interventions) compared with SMT (P 
ISSN:0269-2813
1365-2036
DOI:10.1111/j.1365-2036.2007.03277.x