Incidence of hip fracture over a 10-year period (1991–2000): Reversal of a secular trend

• Published in: Bone (New York, N.Y.) N.Y.), 2007-05, Vol.40 (5), p.1284-1289
• Main Authors: Chevalley, T, Guilley, E, Herrmann, F.R, Hoffmeyer, P, Rapin, C.-H, Rizzoli, R
• Format: Article
• Language: English
• Subjects: Age Distribution; Aged; Aged, 80 and over; Biological and medical sciences; Diseases of the osteoarticular system; Epidemiology; Female; Hip fracture; Hip Fractures - epidemiology; Hip Fractures - pathology; Humans; Incidence; Injuries of the limb. Injuries of the spine; Male; Medical sciences; Middle Aged; Orthopedics; Osteoporosis; Osteoporosis. Osteomalacia. Paget disease; Sex Characteristics; Time Factors; Traumas. Diseases due to physical agents; Trend
• ISSN: 8756-3282; 1873-2763
• DOI: 10.1016/j.bone.2006.12.063

Abstract Introduction Hip fractures are a major cause of burden associated with osteoporosis in terms of mortality, disability, and costs. With the ageing of the population, a marked increase in the number of fractures is expected. Furthermore, many studies reveal an increase of the age-adjusted hip fracture incidence. We specifically examined secular changes in the incidence of hip fracture in women and men aged 50 years and over in the well-defined area of Geneva, Switzerland. Materials and methods All hip fractured patients were retrospectively identified from the computer medical records of the main hospital, which is receiving 95% of hip fractures occurring in a well-defined area. Results From 1991 to 2000, 4115 hip fractures were recorded in 2981 women and 822 men with a mean age (± S.D.) of 83.1 ± 8.9 and 78.3 ± 11.6 years, respectively. A second hip fracture occurred in 276 women (9.3%) and 36 men (4.4%), on average 2.1 ± 1.9 (median 1.44) years after the first event without gender difference. The overall incidence of hip fractures was 455 (95% CI: 439–471) per 100,000 person-years in women and 153 (95% CI: 143–163) in men. The number of hip fractures remained constant (412 (95% CI: 397–426)), but the mean age of these patients increased each year by 0.13 year in women ( p = 0.019) and by 0.04 year in men (NS). Furthermore, the age-adjusted incidence of hip fractures, standardized to the 2000 Geneva population, decreased significantly by 1.4% (95% CI: − 2.6 to − 0.1) per year in women ( p = 0.021), but remained stable in men (0.5% (95% CI: − 1.7 to + 2.8) per year, p = 0.66). The overall female/male ratio of hip fracture incidence was 2.99 (95% CI: 2.80–3.18, p < 0.001) and significantly decreased by 0.07 (95% CI: − 0.13 to − 0.01) per year ( p = 0.024). Conclusion Despite an increase in the population at risk and in the mean age of hip fractured women, there was a significant decrease in age-adjusted incidence in women but not in men. These results may suggest a reversal of the previously observed secular trend.