Value of Electrocardiographically Gated Single-Photon Emission Computed Tomographic Myocardial Perfusion Scintigraphy in a Cohort of Symptomatic Postmenopausal Women

• Published in: The American journal of cardiology 2007-04, Vol.99 (8), p.1096-1099
• Main Authors: Mieres, Jennifer H., MD, Makaryus, Amgad N., MD, Cacciabaudo, Jean M., MD, Donaldson, David, MD, Green, Stephen J., MD, Heller, Gary V., MD, Maddahi, Jamshid, MD, Ong, Lawrence, MD, Rampersaud, Tilkawatee, RN, Rosen, Stacey E., MD, Shaw, Leslee J., PhD, Katz, Stanley, MD
• Format: Article
• Language: English
• Subjects: Adenosine; Aged; Angina Pectoris - diagnostic imaging; Cardiology; Cardiovascular; Cardiovascular disease; Clinical outcomes; Cohort Studies; Coronary Angiography; Coronary Circulation - physiology; Coronary Disease - diagnosis; Coronary vessels; Electrocardiography; Exercise Test; Female; Follow-Up Studies; Heart; Hospitalization; Humans; Medical imaging; Menopause; Myocardial Infarction - diagnosis; Myocardial Ischemia - diagnostic imaging; Postmenopause - physiology; Prospective Studies; Radiopharmaceuticals; Risk Factors; Sensitivity and Specificity; Survival analysis; Survival Rate; Technetium Tc 99m Sestamibi; Tomography; Tomography, Emission-Computed, Single-Photon; Vasodilator Agents
• ISSN: 0002-9149; 1879-1913
• DOI: 10.1016/j.amjcard.2006.12.024

The aim of this study is to prospectively evaluate the clinical value of electrocardiographically gated single-photon emission computed tomographic myocardial perfusion scintigraphy (MPS) imaging in a cohort of postmenopausal women with symptoms suggestive of ischemic heart disease. Forty-six postmenopausal women with no history of coronary artery disease (CAD), but with typical or atypical angina and ≥1 risk factor for CAD, were enrolled and underwent both coronary angiography and technetium-99m sestamibi MPS with exercise (n = 36) or pharmacologic stress (n = 10). All women were followed up for 5.0 ± 3 years for the occurrence of hospitalization for acute coronary syndrome, myocardial infarction, and/or new-onset or worsening angina. CAD prevalence (≥50% diameter stenosis) was 62% (26 of 42 patients). Fifteen patients (36%) had 1-vessel disease, 7 (17%) had 2-vessel disease, and 4 (10%) had 3-vessel disease. Diagnostic sensitivity and specificity of the exercise electrocardiogram were 67% and 69%, respectively. By comparison, sensitivity of MPS was 88% and specificity was 87.5% (p