DOUBLE INVASIVE FUNGAL INFECTION AND TYPHLITIS IN CHILDREN WITH ACUTE LYMPHOBLASTIC LEUKEMIA

Invasive fungal infection is one of the major causes of morbidity and mortality in immunocompromised patients. The occurrence of two invasive fungal infections in one patient at the same time is quite rare. Here the authors report on two adolescent patients with acute lymphoblastic leukemia who deve...

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Bibliographic Details
Published in:Pediatric hematology and oncology 2008-01, Vol.25 (2), p.99-106
Main Authors: Avci, Zekai, Alioglu, Bulent, Anuk, Deniz, Ozbek, Ozlem Yilmaz, Azap, Ozlem Kurt, Ozbek, Namik
Format: Article
Language:English
Subjects:
acute lymphoblastic leukemia
Adolescent
Amphotericin B - administration & dosage
Antifungal Agents - administration & dosage
Aspergillosis - diagnostic imaging
Aspergillosis - drug therapy
Aspergillosis - etiology
Aspergillosis - microbiology
Candidiasis - diagnostic imaging
Candidiasis - drug therapy
Candidiasis - etiology
Candidiasis - microbiology
Candidiasis - pathology
Fatal Outcome
hepatosplenic candidiasis
Humans
Immunocompromised Host
invasive fungal infection
invasive pulmonary aspergillosis
Liver Diseases - diagnostic imaging
Liver Diseases - drug therapy
Liver Diseases - etiology
Liver Diseases - microbiology
Lung Diseases, Fungal - diagnostic imaging
Lung Diseases, Fungal - drug therapy
Lung Diseases, Fungal - etiology
Lung Diseases, Fungal - microbiology
Male
neutropenic enterocolitis
Precursor Cell Lymphoblastic Leukemia-Lymphoma - complications
Precursor Cell Lymphoblastic Leukemia-Lymphoma - diagnostic imaging
Precursor Cell Lymphoblastic Leukemia-Lymphoma - drug therapy
Precursor Cell Lymphoblastic Leukemia-Lymphoma - microbiology
Radiography
Splenic Diseases - diagnostic imaging
Splenic Diseases - drug therapy
Splenic Diseases - etiology
Splenic Diseases - microbiology
Typhlitis - diagnostic imaging
Typhlitis - drug therapy
Typhlitis - etiology
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Description
Summary:Invasive fungal infection is one of the major causes of morbidity and mortality in immunocompromised patients. The occurrence of two invasive fungal infections in one patient at the same time is quite rare. Here the authors report on two adolescent patients with acute lymphoblastic leukemia who developed combined invasive pulmonary aspergillosis and hepatosplenic candidiasis during chemotherapy. They were treated with liposomal amphotericin B, but one of them died due to massive pulmonary hemorrhage during recovery from neutropenia.
ISSN:0888-0018
1521-0669
DOI:10.1080/08880010701885235