Assessment of health-related quality of life of adolescent cancer patients using the Minneapolis-Manchester Quality of Life Adolescent Questionnaire

Background Improved survival after childhood cancer has shifted the focus to health‐related quality of life (HRQL)—an understudied problem, especially among adolescents. Procedure We assessed HRQL among adolescents utilizing a validated self‐report tool, the Minneapolis‐Manchester Quality of Life (M...

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Bibliographic Details
Published in:Pediatric blood & cancer 2007-06, Vol.48 (7), p.678-686
Main Authors: Wu, Eric, Robison, Leslie L., Jenney, Meriel E.M., Rockwood, Todd H., Feusner, James, Friedman, Debra, Kane, Robert L., Bhatia, Smita
Format: Article
Language:English
Subjects:
Adolescent
adolescents
Adult
cancer survivors
Cross-Sectional Studies
Female
Humans
Male
Multivariate Analysis
Neoplasms - diagnosis
Neoplasms - psychology
Neoplasms - therapy
QoL
Quality of Life
Sickness Impact Profile
Surveys and Questionnaires
United States
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Summary:Background Improved survival after childhood cancer has shifted the focus to health‐related quality of life (HRQL)—an understudied problem, especially among adolescents. Procedure We assessed HRQL among adolescents utilizing a validated self‐report tool, the Minneapolis‐Manchester Quality of Life (MMQL) Adolescent Form, consisting of 46 items comprising seven domains: physical, cognitive, psychological and social functioning, body image, intimate relations, and outlook on life, and computed an overall QoL score. The MMQL Adolescent Form was administered to 226 adolescent survivors of childhood cancer a median of 7.8 years from diagnosis (off therapy—median age: 16.2 years), 136 adolescent cancer patients undergoing therapy (on therapy—median age: 16.4 years), and 134 healthy adolescents (controls—median age: 15.5 years). Primary diagnoses included leukemia (46%), lymphoma (26%), brain tumors (5%), and other solid tumors (23%). Results Compared to healthy controls, on‐therapy patients were at increased risk for reporting poor overall QoL [Odds Ratio (OR) = 3.3, P = 0.002)] and poor physical functioning (OR = 11.8, P 
ISSN:1545-5009
1545-5017
DOI:10.1002/pbc.20874