Single-fiber electromyography of masseter muscle in myasthenia gravis

Jitter after axonal microstimulation in the masseter muscle was studied in 30 consecutive patients (12 women) with myasthenia gravis (MG). Patients' mean age was 42.3 (12–75), median disease duration was 3 months (1–72), and onset was ocular (15 cases), oculobulbar (7), bulbar (6), or generaliz...

Full description

Saved in:
Bibliographic Details
Published in:Muscle & nerve 2008-04, Vol.37 (4), p.522-525
Main Authors: Khuraibet, Adnan J., Rousseff, Rossen T., Behbehani, Raed, Al-Shubaili, Asmahan F.K., Khan, Riyadh A.
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Biological and medical sciences
Child
Diseases of striated muscles. Neuromuscular diseases
Electric Stimulation
Electromyography - methods
end plate jitter
Female
Fundamental and applied biological sciences. Psychology
Humans
Male
masseter muscle
Masseter Muscle - innervation
Masseter Muscle - physiology
Medical sciences
Middle Aged
Muscle Fibers, Skeletal - physiology
myasthenia gravis
Myasthenia Gravis - diagnosis
Myasthenia Gravis - physiopathology
Neurology
neuromuscular transmission disorders
Peripheral nervous system. Autonomic nervous system. Neuromuscular transmission. Ganglionic transmission. Electric organ
Sensitivity and Specificity
single-fiber electromyography
Vertebrates: nervous system and sense organs
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Jitter after axonal microstimulation in the masseter muscle was studied in 30 consecutive patients (12 women) with myasthenia gravis (MG). Patients' mean age was 42.3 (12–75), median disease duration was 3 months (1–72), and onset was ocular (15 cases), oculobulbar (7), bulbar (6), or generalized (2). There were 23 newly‐diagnosed patients. Nine cases developed purely ocular MG and 21 cases developed generalized MG. In the latter group, five subjects had a rapidly progressive course and 16 subjects had stable or well‐controlled disease (MGFA grade 2–3). Six patients did not have circulating anti–acetylcholine receptor antibodies. Masseter single‐fiber electromyography (SFEMG) was abnormal in 6 of 9 ocular MG patients and in all generalized cases (overall sensitivity 27 of 30 cases or 90%; confidence interval 79.3%–100.0% at P = 0.95). Masseter should be considered for SFEMG in diagnosis of MG, especially in cases with bulbar onset. Muscle Nerve, 2007
ISSN:0148-639X
1097-4598
DOI:10.1002/mus.20921