Lower specific micronutrient intake in colorectal cancer patients with tumors presenting promoter hypermethylation in p16(INK4a), p4(ARF) and hMLH1

The diversity of the Mediterranean diet and the heterogeneity of acquired epigenetic alterations in colorectal cancer (CRC) led us to examine the possible association between dietary factors and promoter hypermethylation in genes implicated in the pathogenesis of these neoplasms (p16(INK4a), p14(ARF...

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Bibliographic Details
Published in:Anticancer research 2007-03, Vol.27 (2), p.1151-1156
Main Authors: Mas, Sergi, Lafuente, M Jose, Crescenti, Anna, Trias, Manuel, Ballesta, Antonio, Molina, Rafael, Zheng, Shichun, Wiencke, John K, Lafuente, Amalia
Format: Article
Language:English
Subjects:
Adaptor Proteins, Signal Transducing
Alleles
Carrier Proteins - genetics
Case-Control Studies
Colorectal Neoplasms - genetics
Colorectal Neoplasms - prevention & control
Cyclin-Dependent Kinase Inhibitor p16 - genetics
Diet
DNA Methylation
Female
Humans
Male
Methylenetetrahydrofolate Reductase (NADPH2) - genetics
Micronutrients - administration & dosage
MutL Protein Homolog 1
Nuclear Proteins - genetics
Polymorphism, Genetic
Promoter Regions, Genetic
Tumor Suppressor Protein p14ARF - genetics
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Summary:The diversity of the Mediterranean diet and the heterogeneity of acquired epigenetic alterations in colorectal cancer (CRC) led us to examine the possible association between dietary factors and promoter hypermethylation in genes implicated in the pathogenesis of these neoplasms (p16(INK4a), p14(ARF), hMLH1) and the interaction with methylene tetrahydrofolate reductase (MTHFR) C677T polymorphism. For the molecular study, 120 CRC patients were analyzed for hMLH1 promoter methylation status and MTHFR genotyping. Dietary patterns and molecular data on p16(INK4a) and p14(ARF) methylation were obtained from previous studies with this populations. Patients with methylation in p16(INK4a) consumed significantly less folate (p = 0.01), vitamin A (p = 0.01), vitamin B1 (p = 0.007), potassium (p = 0.03) and iron (p = 0.02) than controls. Patients with methylation in p14(ARF) or hMLH1 consumed significantly less vitamin A (p = 0.001 and p = 0.05, respectively). These results support that certain micronutrients protect against colorectal neoplasia and emphasize the importance of considering the different molecular forms of CRC as etiologically distinct diseases.
ISSN:0250-7005