Mass spectrometry for enzyme assays and inhibitor screening: An emerging application in pharmaceutical research

Robust methods that monitor enzyme activity and inhibitor potency are crucial to drug discovery and development. Over the past 20 years, mass spectrometric methods have increasingly been used to measure enzyme activity and kinetics. However, for rapid screening of inhibitory compounds, various forms...

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Bibliographic Details
Published in:Mass spectrometry reviews 2007-05, Vol.26 (3), p.324-339
Main Author: Greis, Kenneth D.
Format: Article
Language:English
Subjects:
Biological Assay - trends
compound screening
Drug Design
enzyme activity
enzyme assays
Enzyme Inhibitors - chemistry
Enzymes - chemistry
Forecasting
kinetics
mass spectrometry
Mass Spectrometry - trends
Research Design - trends
Technology, Pharmaceutical - trends
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