Physical Characterization of Component Particles Included in Dry Powder Inhalers. II. Dynamic Characteristics

• Published in: Journal of pharmaceutical sciences 2007-05, Vol.96 (5), p.1302-1319
• Main Authors: Hickey, Anthony J., Mansour, Heidi M., Telko, Martin J., Xu, Zhen, Smyth, Hugh D.C., Mulder, Tako, McLean, Richard, Langridge, John, Papadopoulos, Dimitris
• Format: Article
• Language: English
• Subjects: Administration, Inhalation; Aerosols; Albuterol - administration & dosage; Albuterol - chemistry; Biological and medical sciences; Bronchodilator Agents - administration & dosage; Bronchodilator Agents - chemistry; Chemistry, Pharmaceutical; Crystallization; Drug Carriers; General pharmacology; Lactose - chemistry; Medical sciences; microparticles; Nebulizers and Vaporizers; Pharmaceutical technology. Pharmaceutical industry; Pharmacology. Drug treatments; physical characterization; physicochemical; powder technology; Powders; pulmonary; pulmonary drug delivery; solid state; static charge; Static Electricity; surface chemistry; Technology, Pharmaceutical - methods
• ISSN: 0022-3549; 1520-6017
• DOI: 10.1002/jps.20943

Characteristics of particles included in dry powder inhalers is extended from our previous report (in this journal) to include properties related to their dynamic performance. The performance of dry powder aerosols for pulmonary delivery is known to depend on fluidization and dispersion which reflects particle interactions in static powder beds. Since the solid state, surface/interfacial chemistry and static bulk properties were assessed previously, it remains to describe dynamic performance with a view to interpreting the integrated database. These studies result in complex data matrices from which correlations between specific properties and performance may be deduced. Lactose particles were characterized in terms of their dynamic flow, powder and aerosol electrostatics, and aerodynamic performance with respect to albuterol aerosol dispersion. There were clear correlations between flow properties and aerosol dispersion that would allow selection of lactose particles for formulation. Moreover, these properties can be related to data reported earlier on the morphological and surface properties of the carrier lactose particles. The proposed series of analytical approaches to the evaluation of powders for inclusion in aerosol products has merit and may be the basis for screening and ultimately predicting particle performance with a view to formulation optimization.