Atrioventricular Valvular Angiectasis in Sprague-Dawley Rats

Subendothelial heart valve angiectasis has been reported in cows, dogs, pigs, rats, mice, and in human fetuses and newborns. We observed a high incidence (62 in 208 animals examined) of spontaneous angiectasis on the atrioventricular (AV) valves in 10- to 40-week-old Sprague-Dawley rats. The angiect...

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Bibliographic Details
Published in:Veterinary pathology 2007-05, Vol.44 (3), p.407-410
Main Authors: Fang, H, Howroyd, P.C, Fletcher, A.M, Diters, R.W, Woicke, J, Sasseville, V.G, Bregman, C.L, Freebern, W.J, Durham, S.K, Mense, M.G
Format: Article
Language:English
Subjects:
Animals
atrioventricular valves
disease incidence
Female
heart diseases
Heart Valve Diseases - pathology
Heart Valve Diseases - veterinary
heart valves
hematocysts
histopathology
laboratory animals
Male
Rats
Rats, Sprague-Dawley
Rodent Diseases - pathology
valvular cysts
Vascular Diseases - pathology
Vascular Diseases - veterinary
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Summary:Subendothelial heart valve angiectasis has been reported in cows, dogs, pigs, rats, mice, and in human fetuses and newborns. We observed a high incidence (62 in 208 animals examined) of spontaneous angiectasis on the atrioventricular (AV) valves in 10- to 40-week-old Sprague-Dawley rats. The angiectasis was observed predominately on the septal cusp of the right AV valve and located near the AV ostium in 57 of 62 animals. Of the remaining 5 valvular angiectases, 2 were present on the parietal cusp of the right AV valve and 3 were on the left AV valve. The angiectases were single or multiple, ranging from 40 to 300 μm in diameter and were characterized by light microscopy as blood-filled dilatations lined by endothelium. Spontaneously occurring abnormalities in normal laboratory animals, such as the spontaneous valvular angiectasis reported here, need to be differentiated from drug-related lesions.
ISSN:0300-9858
1544-2217
DOI:10.1354/vp.44-3-407