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Ethnicity and Nonalcoholic Fatty Liver Disease in an Obesity Clinic: The Impact of Triglycerides
Nonalcoholic fatty liver disease (NAFLD) is a growing problem that is associated with the metabolic syndrome. The goal of the present study was to evaluate for ethnic differences in NAFLD and clinical correlates of NAFLD. The study population consisted of 567 patients seen at an urban obesity clinic...
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| Published in: | Digestive diseases and sciences 2008-05, Vol.53 (5), p.1358-1363 |
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| cites | cdi_FETCH-LOGICAL-c399t-14ed6d9592801a417196b6af88a735ef18f90574240a6c106d477efb2bda5ef3 |
| container_end_page | 1363 |
| container_issue | 5 |
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| container_title | Digestive diseases and sciences |
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| creator | Kallwitz, Eric R. Kumar, Mrudula Aggarwal, Radhika Berger, Reed Layden-Almer, Jennifer Gupta, Neil Cotler, Scott J. |
| description | Nonalcoholic fatty liver disease (NAFLD) is a growing problem that is associated with the metabolic syndrome. The goal of the present study was to evaluate for ethnic differences in NAFLD and clinical correlates of NAFLD. The study population consisted of 567 patients seen at an urban obesity clinic. Elevated aminotransferase levels were used as a surrogate marker for NAFLD. The prevalence of elevated aminotransferases was highest in Hispanics (39%), followed by Caucasians (28%), and African Americans (12%). In univariate analysis, elevated aminotransferase levels were associated with ethnicity (Hispanic > African American,
P
African American
P
= 0.030), hypertriglyceridemia (
P
|
| doi_str_mv | 10.1007/s10620-008-0234-x |
| format | article |
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P
< 0.001, and Caucasian > African American
P
= 0.030), hypertriglyceridemia (
P
< 0.001), and male gender (
P
< 0.001). The pattern of results was confirmed in multivariate analysis, except that the differences between Caucasians and African Americans was no longer significant. In conclusion, in an obesity clinic population, elevated aminotransferase levels and hypertriglyceridemia were most common in Hispanics and least common in African Americans.</description><identifier>ISSN: 0163-2116</identifier><identifier>EISSN: 1573-2568</identifier><identifier>DOI: 10.1007/s10620-008-0234-x</identifier><identifier>PMID: 18347982</identifier><identifier>CODEN: DDSCDJ</identifier><language>eng</language><publisher>Boston: Springer US</publisher><subject>Adult ; Alanine Transaminase - blood ; Analysis of Variance ; Biochemistry ; Biological and medical sciences ; Chicago - epidemiology ; Fatty Liver - epidemiology ; Fatty Liver - ethnology ; Feeding. Feeding behavior ; Female ; Fundamental and applied biological sciences. Psychology ; Gastroenterology ; Gastroenterology. Liver. Pancreas. Abdomen ; Hepatology ; Humans ; Hypertriglyceridemia - epidemiology ; Hypertriglyceridemia - ethnology ; Liver. Biliary tract. Portal circulation. Exocrine pancreas ; Male ; Medical sciences ; Medicine ; Medicine & Public Health ; Metabolic diseases ; Obesity ; Obesity - epidemiology ; Obesity - ethnology ; Oncology ; Original Paper ; Other diseases. Semiology ; Prevalence ; Retrospective Studies ; Risk Factors ; Transplant Surgery ; Urban Population ; Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><ispartof>Digestive diseases and sciences, 2008-05, Vol.53 (5), p.1358-1363</ispartof><rights>Springer Science+Business Media, LLC 2008</rights><rights>2008 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c399t-14ed6d9592801a417196b6af88a735ef18f90574240a6c106d477efb2bda5ef3</citedby><cites>FETCH-LOGICAL-c399t-14ed6d9592801a417196b6af88a735ef18f90574240a6c106d477efb2bda5ef3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20309274$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18347982$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kallwitz, Eric R.</creatorcontrib><creatorcontrib>Kumar, Mrudula</creatorcontrib><creatorcontrib>Aggarwal, Radhika</creatorcontrib><creatorcontrib>Berger, Reed</creatorcontrib><creatorcontrib>Layden-Almer, Jennifer</creatorcontrib><creatorcontrib>Gupta, Neil</creatorcontrib><creatorcontrib>Cotler, Scott J.</creatorcontrib><title>Ethnicity and Nonalcoholic Fatty Liver Disease in an Obesity Clinic: The Impact of Triglycerides</title><title>Digestive diseases and sciences</title><addtitle>Dig Dis Sci</addtitle><addtitle>Dig Dis Sci</addtitle><description>Nonalcoholic fatty liver disease (NAFLD) is a growing problem that is associated with the metabolic syndrome. The goal of the present study was to evaluate for ethnic differences in NAFLD and clinical correlates of NAFLD. The study population consisted of 567 patients seen at an urban obesity clinic. Elevated aminotransferase levels were used as a surrogate marker for NAFLD. The prevalence of elevated aminotransferases was highest in Hispanics (39%), followed by Caucasians (28%), and African Americans (12%). In univariate analysis, elevated aminotransferase levels were associated with ethnicity (Hispanic > African American,
P
< 0.001, and Caucasian > African American
P
= 0.030), hypertriglyceridemia (
P
< 0.001), and male gender (
P
< 0.001). The pattern of results was confirmed in multivariate analysis, except that the differences between Caucasians and African Americans was no longer significant. In conclusion, in an obesity clinic population, elevated aminotransferase levels and hypertriglyceridemia were most common in Hispanics and least common in African Americans.</description><subject>Adult</subject><subject>Alanine Transaminase - blood</subject><subject>Analysis of Variance</subject><subject>Biochemistry</subject><subject>Biological and medical sciences</subject><subject>Chicago - epidemiology</subject><subject>Fatty Liver - epidemiology</subject><subject>Fatty Liver - ethnology</subject><subject>Feeding. Feeding behavior</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gastroenterology</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Hepatology</subject><subject>Humans</subject><subject>Hypertriglyceridemia - epidemiology</subject><subject>Hypertriglyceridemia - ethnology</subject><subject>Liver. Biliary tract. Portal circulation. Exocrine pancreas</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Metabolic diseases</subject><subject>Obesity</subject><subject>Obesity - epidemiology</subject><subject>Obesity - ethnology</subject><subject>Oncology</subject><subject>Original Paper</subject><subject>Other diseases. Semiology</subject><subject>Prevalence</subject><subject>Retrospective Studies</subject><subject>Risk Factors</subject><subject>Transplant Surgery</subject><subject>Urban Population</subject><subject>Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><issn>0163-2116</issn><issn>1573-2568</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><recordid>eNp1kE1vEzEQhi0EoqHwA7ggCwluCzNerz-4VaGFShG95G683tnG1WY32BvU_HscJaISEidbnued8TyMvUX4hAD6c0ZQAioAU4GoZfX4jC2w0XUlGmWeswWgKndEdcFe5fwAAFajesku0NRSWyMW7Of1vBljiPOB-7HjP6bRD2HaTEMM_MbP5XkVf1PiX2Mmn4nHsXD8rqV8jCyHWMJf-HpD_Ha782HmU8_XKd4Ph0ApdpRfsxe9HzK9OZ-XbH1zvV5-r1Z3326XV6sq1NbOFUrqVGcbKwygl6jRqlb53hiv64Z6NL2FRkshwatQ9u6k1tS3ou18KdeX7OOp7S5Nv_aUZ7eNOdAw-JGmfXYapLECbAHf_wM-TPtUts5OoKwFCiULhCcopCnnRL3bpbj16eAQ3FG9O6l3Rb07qnePJfPu3Hjfbql7SpxdF-DDGfA5-KFPfgwx_-UE1GCFPg4XJy6X0nhP6emH_5_-ByNdmsY</recordid><startdate>20080501</startdate><enddate>20080501</enddate><creator>Kallwitz, Eric R.</creator><creator>Kumar, Mrudula</creator><creator>Aggarwal, Radhika</creator><creator>Berger, Reed</creator><creator>Layden-Almer, Jennifer</creator><creator>Gupta, Neil</creator><creator>Cotler, Scott J.</creator><general>Springer US</general><general>Springer</general><general>Springer Nature B.V</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope></search><sort><creationdate>20080501</creationdate><title>Ethnicity and Nonalcoholic Fatty Liver Disease in an Obesity Clinic: The Impact of Triglycerides</title><author>Kallwitz, Eric R. ; Kumar, Mrudula ; Aggarwal, Radhika ; Berger, Reed ; Layden-Almer, Jennifer ; Gupta, Neil ; Cotler, Scott J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c399t-14ed6d9592801a417196b6af88a735ef18f90574240a6c106d477efb2bda5ef3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Adult</topic><topic>Alanine Transaminase - blood</topic><topic>Analysis of Variance</topic><topic>Biochemistry</topic><topic>Biological and medical sciences</topic><topic>Chicago - epidemiology</topic><topic>Fatty Liver - epidemiology</topic><topic>Fatty Liver - ethnology</topic><topic>Feeding. Feeding behavior</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gastroenterology</topic><topic>Gastroenterology. Liver. Pancreas. Abdomen</topic><topic>Hepatology</topic><topic>Humans</topic><topic>Hypertriglyceridemia - epidemiology</topic><topic>Hypertriglyceridemia - ethnology</topic><topic>Liver. Biliary tract. Portal circulation. Exocrine pancreas</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Metabolic diseases</topic><topic>Obesity</topic><topic>Obesity - epidemiology</topic><topic>Obesity - ethnology</topic><topic>Oncology</topic><topic>Original Paper</topic><topic>Other diseases. Semiology</topic><topic>Prevalence</topic><topic>Retrospective Studies</topic><topic>Risk Factors</topic><topic>Transplant Surgery</topic><topic>Urban Population</topic><topic>Vertebrates: anatomy and physiology, studies on body, several organs or systems</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kallwitz, Eric R.</creatorcontrib><creatorcontrib>Kumar, Mrudula</creatorcontrib><creatorcontrib>Aggarwal, Radhika</creatorcontrib><creatorcontrib>Berger, Reed</creatorcontrib><creatorcontrib>Layden-Almer, Jennifer</creatorcontrib><creatorcontrib>Gupta, Neil</creatorcontrib><creatorcontrib>Cotler, Scott J.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database (ProQuest)</collection><collection>ProQuest - Health & Medical Complete保健、医学与药学数据库</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>Consumer Health Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Family Health Database (Proquest)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><jtitle>Digestive diseases and sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kallwitz, Eric R.</au><au>Kumar, Mrudula</au><au>Aggarwal, Radhika</au><au>Berger, Reed</au><au>Layden-Almer, Jennifer</au><au>Gupta, Neil</au><au>Cotler, Scott J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Ethnicity and Nonalcoholic Fatty Liver Disease in an Obesity Clinic: The Impact of Triglycerides</atitle><jtitle>Digestive diseases and sciences</jtitle><stitle>Dig Dis Sci</stitle><addtitle>Dig Dis Sci</addtitle><date>2008-05-01</date><risdate>2008</risdate><volume>53</volume><issue>5</issue><spage>1358</spage><epage>1363</epage><pages>1358-1363</pages><issn>0163-2116</issn><eissn>1573-2568</eissn><coden>DDSCDJ</coden><abstract>Nonalcoholic fatty liver disease (NAFLD) is a growing problem that is associated with the metabolic syndrome. The goal of the present study was to evaluate for ethnic differences in NAFLD and clinical correlates of NAFLD. The study population consisted of 567 patients seen at an urban obesity clinic. Elevated aminotransferase levels were used as a surrogate marker for NAFLD. The prevalence of elevated aminotransferases was highest in Hispanics (39%), followed by Caucasians (28%), and African Americans (12%). In univariate analysis, elevated aminotransferase levels were associated with ethnicity (Hispanic > African American,
P
< 0.001, and Caucasian > African American
P
= 0.030), hypertriglyceridemia (
P
< 0.001), and male gender (
P
< 0.001). The pattern of results was confirmed in multivariate analysis, except that the differences between Caucasians and African Americans was no longer significant. In conclusion, in an obesity clinic population, elevated aminotransferase levels and hypertriglyceridemia were most common in Hispanics and least common in African Americans.</abstract><cop>Boston</cop><pub>Springer US</pub><pmid>18347982</pmid><doi>10.1007/s10620-008-0234-x</doi><tpages>6</tpages></addata></record> |
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| subjects | Adult Alanine Transaminase - blood Analysis of Variance Biochemistry Biological and medical sciences Chicago - epidemiology Fatty Liver - epidemiology Fatty Liver - ethnology Feeding. Feeding behavior Female Fundamental and applied biological sciences. Psychology Gastroenterology Gastroenterology. Liver. Pancreas. Abdomen Hepatology Humans Hypertriglyceridemia - epidemiology Hypertriglyceridemia - ethnology Liver. Biliary tract. Portal circulation. Exocrine pancreas Male Medical sciences Medicine Medicine & Public Health Metabolic diseases Obesity Obesity - epidemiology Obesity - ethnology Oncology Original Paper Other diseases. Semiology Prevalence Retrospective Studies Risk Factors Transplant Surgery Urban Population Vertebrates: anatomy and physiology, studies on body, several organs or systems |
| title | Ethnicity and Nonalcoholic Fatty Liver Disease in an Obesity Clinic: The Impact of Triglycerides |
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