Progesterone receptor (PROGINS) polymorphism and the risk of ovarian cancer

• Published in: Steroids 2008-07, Vol.73 (6), p.676-680
• Main Authors: Leite, Daniela B., Junqueira, Michele G., de Carvalho, Cristina V., Massad-Costa, Ana M., Gonçalves, Wagner J., Nicolau, Sergio M., Lopes, Luiz A.F., Baracat, Edmundo C., da Silva, Ismael D.C.G.
• Format: Article
• Language: English
• Subjects: Adult; Aged; Biological and medical sciences; Case-Control Studies; Female; Female genital diseases; Fundamental and applied biological sciences. Psychology; Genetic Predisposition to Disease; Gynecology. Andrology. Obstetrics; Humans; Medical sciences; Middle Aged; Ovarian cancer; Ovarian Neoplasms - genetics; Polymorphism; Polymorphism, Genetic; PROGINS; Receptors, Progesterone - genetics; Risk Factors; Tumors; Vertebrates: endocrinology
• ISSN: 0039-128X; 1878-5867
• DOI: 10.1016/j.steroids.2008.02.005

The present case–control study evaluates the role of the progesterone receptor (PR) polymorphism known as PROGINS as a risk factor for ovarian cancer development and investigates the association between these genetic variants and clinical/pathologic variables of ovarian cancer. PROGINS polymorphism was examined, by polymerase chain reaction, in a total of 80 patients with ovarian cancer and 282 control subjects. The frequencies of PROGINS polymorphism T1/T1, T1/T2, and T2/T2 were 71.3, 15.0 and 13.8% in ovarian cancer patients and 78.37, 21.63 and 0% in controls, respectively. The χ 2-test showed a higher incidence of the T2/T2 genotype ( P = 0.001) in the ovarian cancer group. In addition, women carrying a mutated allele (T2) showed approximately 2.2 times higher risk of ovarian cancer development as compared to women who have a variant allele (odds ratio (OR) = 2.2; 95% CI = 1.80–3.54). Regarding the clinical and pathologic findings observed within the cancer group, there was a significant correlation between PROGINS polymorphism and patients with a familial history ( χ 2 = 6.776; P = 0.009; Fischer exact test, P = 0.01). In this regard, patients with familial antecedents have a 4.7 times higher likelihood to have at least one risk allele (T2) as compared with patients without familial antecedents (OR = 4.69; 95% CI = 1.38–15.87). No correlations were observed among the other variables. These data suggest that the PROGINS polymorphism T2/T2 genotype might be associated with an increased risk of ovarian cancer.