Magnetic Resonance Imaging in Children With Bilateral Spastic Forms of Cerebral Palsy

We analyzed the relationship between magnetic resonance image findings in children with bilateral spastic cerebral palsy and its stages of severity in term and preterm children. Magnetic resonance image findings of 102 children (66 male and 36 female) with bilateral spastic cerebral palsy (median ag...

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Published in:Pediatric neurology 2008-05, Vol.38 (5), p.321-328
Main Authors: Sööt, Anu, MD, PhD, Tomberg, Tiiu, MD, PhD, Kool, Pille, BSc, Rein, Reet, MD, Talvik, Tiina, MD, PhD
Format: Article
Language:English
Subjects:
Adolescent
Biological and medical sciences
Brain - pathology
Cerebral Palsy - complications
Child
Child, Preschool
Female
Functional Laterality
Humans
Infant
Investigative techniques, diagnostic techniques (general aspects)
Magnetic Resonance Imaging - methods
Male
Medical sciences
Muscle Spasticity - etiology
Muscle Spasticity - pathology
Nervous system
Neurology
Pediatrics
Radiodiagnosis. Nmr imagery. Nmr spectrometry
Severity of Illness Index
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Summary:We analyzed the relationship between magnetic resonance image findings in children with bilateral spastic cerebral palsy and its stages of severity in term and preterm children. Magnetic resonance image findings of 102 children (66 male and 36 female) with bilateral spastic cerebral palsy (median age, 2.5 years; range, 3 months to 15 years) were reevaluated. The study group consisted of children with confirmed perinatal asphyxia. Hypoxic-ischemic events were diagnosed in 64% of the children. Significant abnormalities relevant to cerebral palsy were evident on imaging in 85/102 (83%) children (in 77% of term and 93% of preterm children). Enlargement of the ventricles alone (48%) or accompanied by periventricular white-matter damage (25%) was the most frequent finding in term and preterm children, but was more highly expressed in preterm children ( P < 0.05). White-matter damage was more often found in preterm children ( P < 0.05). Enlargement of the lateral ventricles and periventricular leukomalacia may be attributable to ischemic damage to the neonatal brain. Significant correlations were found between magnetic resonance image findings and severity of cerebral palsy ( P < 0.05). Detection of brain abnormalities in children with cerebral palsy may prove useful in prognoses as well as in medical consultations and management.
ISSN:0887-8994
1873-5150
DOI:10.1016/j.pediatrneurol.2007.12.011