Effect of phototherapy on blood endothelin and nitric oxide levels: clinical significance in preterm infants

Background Phototherapy may have an adverse effect on the hemodynamics of preterm infants, and endothelin (ET) and nitric oxide (NO) are both the powerful vasoactive substances. This study was designed to observe the effect of phototherapy on blood levels of ET and NO in preterm infants. Methods Six...

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Bibliographic Details
Published in:World journal of pediatrics : WJP 2008-02, Vol.4 (1), p.31-35
Main Authors: Liu, Guo-Sheng, Wu, Hui, Wu, Ben-Qing, Huang, Run-Zhong, Zhao, Li-Hua, Wen, Yan
Format: Article
Language:English
Subjects:
Blood Pressure
Critical Care Medicine
Endothelins - blood
Female
Heart Rate
Humans
Hyperbilirubinemia, Neonatal - therapy
Imaging
Infant, Newborn
Infant, Premature
Infant, Premature, Diseases - therapy
Intensive
Male
Maternal and Child Health
Medicine
Medicine & Public Health
Nitric Oxide - blood
Original Article
Pediatric Surgery
Pediatrics
Phototherapy - adverse effects
Radiology
Surgery
Treatment Outcome
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Summary:Background Phototherapy may have an adverse effect on the hemodynamics of preterm infants, and endothelin (ET) and nitric oxide (NO) are both the powerful vasoactive substances. This study was designed to observe the effect of phototherapy on blood levels of ET and NO in preterm infants. Methods Sixty-four preterm infants with hyperbilirubinemia requiring phototherapy were studied. Among them, 31 patients were born at 32–36 weeks’ gestational age (GA), and 33 patients were ≤32 weeks GA. Control group included 26 full-term infants with hyperbilirubinemia requiring phototherapy. All patients were treated with continuous phototherapy for 24 hours. Blood samples were collected before and after phototherapy. The amount of ET in the blood samples was determined by radioimmunoassay, and NO levels were determined using nitrate reductase. Heart rate, respiratory rate, apnea, and mean arterial blood pressure (MABP) were monitored regularly (defined interval: hourly, 4 hours, etc) during phototherapy. Results Blood ET levels measured after 24 hours of phototherapy were higher than the pretreatment values, as were blood NO levels measured after 12 hours and 24 hours of phototherapy. Both increases were statistically significant ( P 32 weeks group, blood NO levels measured after 24 hours of phototherapy were higher than the pretreatment values; these changes were also statistically significant ( P
ISSN:1708-8569
DOI:10.1007/s12519-008-0006-x