Development and physiological regulation of intestinal lipid absorption. III. Intestinal transporters and cholesterol absorption

Intestinal cholesterol absorption is modulated by transport proteins in enterocytes. Cholesterol uptake from intestinal lumen requires several proteins on apical brush-border membranes, including Niemann-Pick C1-like 1 (NPC1L1), scavenger receptor B-I, and CD36, whereas two ATP-binding cassette half...

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Bibliographic Details
Published in:American journal of physiology: Gastrointestinal and liver physiology 2008-04, Vol.294 (4), p.G839-G843
Main Authors: Hui, David Y, Labonté, Eric D, Howles, Philip N
Format: Article
Language:English
Subjects:
Adenosine triphosphatase
Animals
Anticholesteremic Agents - pharmacology
ATP-Binding Cassette Transporters - metabolism
Azetidines - pharmacology
Binding sites
CD36 Antigens - metabolism
Cholesterol
Cholesterol - metabolism
Ezetimibe
Humans
Intestinal Absorption - drug effects
Intestinal Mucosa - metabolism
Intestines - drug effects
Intestines - immunology
Intestines - metabolism
Lipids
Membrane Proteins - metabolism
Membrane Transport Proteins - metabolism
Proteins
Scavenger Receptors, Class B - metabolism
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Summary:Intestinal cholesterol absorption is modulated by transport proteins in enterocytes. Cholesterol uptake from intestinal lumen requires several proteins on apical brush-border membranes, including Niemann-Pick C1-like 1 (NPC1L1), scavenger receptor B-I, and CD36, whereas two ATP-binding cassette half transporters, ABCG5 and ABCG8, on apical membranes work together for cholesterol efflux back to the intestinal lumen to limit cholesterol absorption. NPC1L1 is essential for cholesterol absorption, but its function as a cell surface transporter or an intracellular cholesterol transport protein needs clarification. Another ATP transporter, ABCA1, is present in the basolateral membrane to mediate HDL secretion from enterocytes.
ISSN:0193-1857
1522-1547
DOI:10.1152/ajpgi.00061.2008