Impact of heart rate on mechanical dyssynchrony and left ventricular contractility in patients with heart failure and normal QRS duration

Aims: The quantification of mechanical dyssynchrony has important diagnostic value and may help to determine optimal therapy in heart failure (HF). We hypothesized that mechanical dyssynchrony may be augmented at increased heart rates in patients with HF and normal QRS duration. Methods and results:...

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Bibliographic Details
Published in:European journal of heart failure 2007-06, Vol.9 (6-7), p.637-643
Main Authors: Kurita, Tairo, Onishi, Katsuya, Dohi, Kaoru, Tanabe, Masaki, Fujimoto, Naoki, Tanigawa, Takashi, Setsuda, Morimichi, Isaka, Naoki, Nobori, Tsutomu, Ito, Masaaki
Format: Article
Language:English
Subjects:
Aged
Bundle-Branch Block - diagnosis
Bundle-Branch Block - physiopathology
Cardiac Catheterization
Cardiac Pacing, Artificial
conductance catheter
Electrocardiography
Female
heart failure
Heart Failure - diagnosis
Heart Failure - physiopathology
Heart Rate - physiology
Humans
internal flow
Male
mechanical dyssynchrony
Middle Aged
Myocardial Contraction - physiology
patient
Signal Processing, Computer-Assisted
Stroke Volume - physiology
Ventricular Dysfunction, Left - diagnosis
Ventricular Dysfunction, Left - physiopathology
Ventricular Function, Left - physiology
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Summary:Aims: The quantification of mechanical dyssynchrony has important diagnostic value and may help to determine optimal therapy in heart failure (HF). We hypothesized that mechanical dyssynchrony may be augmented at increased heart rates in patients with HF and normal QRS duration. Methods and results: From online segmental conductance catheter signals, we derived indices to quantify temporal and spatial aspects of mechanical dyssynchrony during systole in 20 control subjects, 20 HF patients with normal QRS duration, and 12 HF patients with complete left bundle branch block (CLBBB). Data were collected at baseline, and then following a 40 bpm increase in heart rate induced by right atrial pacing. Mechanical dyssynchrony in HF patients with normal QRS duration or CLBBB was higher than that found in control subjects. In HF patients with normal QRS duration, mechanical dyssynchrony increased from 37.4±4.8% at baseline to 43.2±4.4% with increased heart rate (p
ISSN:1388-9842
1879-0844
DOI:10.1016/j.ejheart.2007.03.002