Association between active GB virus-C (hepatitis G) infection and HIV-1 disease in Uganda

Although not linked to a disease, GB virus-C viraemia has been associated with an improved prognosis in HIV-1-co-infected individuals. Most studies have been conducted on men (men who have sex with men or injection drug users) infected with HIV-1 subtype B, whereas here we report on both male and fe...

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Bibliographic Details
Published in:International journal of STD & AIDS 2007-04, Vol.18 (4), p.244-249
Main Authors: YIRRELL, D. L, WRIGHT, E, SHAFER, L. A, CAMPBELL, E, VAN DER PAAL, L, KALEEBU, P, GROSSKURTH, H, WHITWORTH, J. A
Format: Article
Language:English
Subjects:
Adolescent
Adult
Biological and medical sciences
CD4 Lymphocyte Count
Child
Disease Progression
Epidemiology. Vaccinations
Female
Flaviviridae Infections - classification
Flaviviridae Infections - complications
Flaviviridae Infections - epidemiology
GB virus C - classification
GB virus C - isolation & purification
General aspects
Hepatitis, Viral, Human - classification
Hepatitis, Viral, Human - complications
Hepatitis, Viral, Human - epidemiology
HIV Infections - complications
HIV Infections - epidemiology
HIV Infections - physiopathology
HIV-1 - classification
HIV-1 - pathogenicity
Human immunodeficiency virus 1
Human viral diseases
Humans
Infectious diseases
Male
Medical sciences
Prognosis
Rural Population
Survival Analysis
Uganda - epidemiology
Viral diseases
Viral diseases of the lymphoid tissue and the blood. Aids
Viral hepatitis
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Summary:Although not linked to a disease, GB virus-C viraemia has been associated with an improved prognosis in HIV-1-co-infected individuals. Most studies have been conducted on men (men who have sex with men or injection drug users) infected with HIV-1 subtype B, whereas here we report on both male and female subjects from rural Uganda, predominantly infected via the heterosexual route with HIV-1 subtypes A and D. In a longitudinal study of 272 participants, 47 were GBV-C positive and 181 negative, as determined by reverse transcription-polymerase chain reaction, in both of two plasma samples taken a median of 5.0 years apart. The remainder either acquired (25) or cleared (19) infection. Multilevel regression analyses and Cox survival analyses revealed that participants chronically infected with GBV-C had a slower decline in CD4+ T cells (P
ISSN:0956-4624
1758-1052
DOI:10.1258/095646207780659006