Expanded Criteria for Hepatocellular Carcinoma and Liver Transplantation

Abstract In this study, we evaluated our early results of liver transplantation for hepatocellular carcinoma (HCC). Between January 2004 and June 2006, 26 patients (4 females, 22 males; aged 1.1–65 years) with preoperatively diagnosed or incidental HCC underwent liver transplantation at our center....

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Bibliographic Details
Published in:Transplantation proceedings 2007-05, Vol.39 (4), p.1171-1174
Main Authors: Moray, G, Karakayali, F, Yilmaz, U, Ozcay, F, Bilezikci, B, Haberal, M
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Biological and medical sciences
Carcinoma, Hepatocellular - surgery
Child
Child, Preschool
Female
Fundamental and applied biological sciences. Psychology
Fundamental immunology
Gastroenterology. Liver. Pancreas. Abdomen
Humans
Infant
Liver Neoplasms - surgery
Liver Transplantation - mortality
Liver. Biliary tract. Portal circulation. Exocrine pancreas
Male
Medical sciences
Middle Aged
Patient Selection
Retrospective Studies
Surgery
Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases
Survival Analysis
Survival Rate
Tissue, organ and graft immunology
Tumors
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Summary:Abstract In this study, we evaluated our early results of liver transplantation for hepatocellular carcinoma (HCC). Between January 2004 and June 2006, 26 patients (4 females, 22 males; aged 1.1–65 years) with preoperatively diagnosed or incidental HCC underwent liver transplantation at our center. Inclusion criteria (independent of tumor size and number of tumor nodules) were no invasion of major vascular structures and no evidence of extrahepatic disease. In 13 of the patients, tumors were beyond the Milan criteria. At this writing, at a mean follow-up of 16.5 months (range, 1–31 months), all patients were doing well with excellent graft function. The longest survival is 2.5 years, and our patient survival rate is 100%. There has been only 1 tumor recurrence, which occurred 4 months after liver transplantation. In conclusion, liver transplantation provides long patient and disease-free survival, even in patients with HCC that exceeds the Milan criteria.
ISSN:0041-1345
1873-2623
DOI:10.1016/j.transproceed.2007.02.056