Changes in inflammatory biomarkers following one-year of moderate resistance training in overweight women

• Published in: International Journal of Obesity 2007-06, Vol.31 (6), p.996-1003
• Main Authors: Olson, T.P, Dengel, D.R, Leon, A.S, Schmitz, K.H
• Format: Article
• Language: English
• Subjects: Adhesion; Adipocytes; adiponectin; Adiponectin - blood; Adult; Aerobics; Biological and medical sciences; Biological markers; Biomarkers; Biomarkers - blood; blood chemistry; blood glucose; blood lipids; Blood pressure; Blood Pressure - immunology; Body composition; Body Composition - immunology; Body fat; C-reactive protein; C-Reactive Protein - analysis; Cardiovascular disease; Cardiovascular diseases; cell adhesion; Cell adhesion & migration; Cell Adhesion - immunology; Complications and side effects; Control; Cytokines; Diagnosis; E-selectin; E-Selectin - blood; Enrollments; Epidemiology; Exercise; Exercise Therapy - methods; Feeding. Feeding behavior; Female; Fitness training programs; Fundamental and applied biological sciences. Psychology; Glucose; Health Promotion and Disease Prevention; hormones; Humans; Immunoassays; Inflammation; Inflammation - immunology; Insulin; Intercellular Adhesion Molecule-1 - blood; interleukin-6; Interleukin-6 - blood; Internal Medicine; intracellular adhesion molecule-1; lean body mass; Lipids; Medical sciences; Medicine; Medicine & Public Health; Metabolic Diseases; Metabolism; Obesity; original-article; Overweight; Overweight - immunology; Physical fitness; Physical training; Physiological aspects; proteins; Public Health; Risk factors; Strength training; Vascular Cell Adhesion Molecule-1 - blood; vascular cell adhesions molecule-1; Vertebrates: anatomy and physiology, studies on body, several organs or systems; Weight control; women; Womens health
• ISSN: 0307-0565; 1476-5497
• DOI: 10.1038/sj.ijo.0803534

Background: Overweight individuals commonly demonstrate elevated levels of inflammatory and cell adhesion molecules. Elevated levels of inflammation and adhesion have been implicated in the pathogenesis of cardiovascular disease. Aerobic exercise has been shown to be effective in altering specific biomarkers of inflammation and cell adhesion; however, little is known regarding the effects of resistance training (RT) on these biomarkers. This study examined the effects of 1 year of moderate-intensity RT on biomarkers of inflammation and adhesion in healthy, overweight women. Methods and Results: Participants included 28 (12 control, 16 RT) overweight (body mass index greater than or equal to 25 kg/m2) women, aged 25-44 years, studied before and after 1 year of RT. C-reactive protein (CRP), interleukin-6 (IL-6), adiponectin, intracellular adhesion molecule-1, vascular cell adhesion molecule-1 and E-selectin were measured by standard enzyme-linked immunosorbent assays. Body composition, blood pressure, fasting blood lipids, glucose and insulin also were assessed. There were no significant changes in blood pressure, fasting blood lipids, glucose or insulin levels in either group after 1 year. There was also no change in body mass or fat mass in either group; however, there was a significant increase in lean body mass (P